Effects of Δ8-tetrahydrocannabinol and its active metabolites on metabolic disposition of pentobarbital in the mouse

K. Watanabe, S. Narimatsu, M. Itoh

Research output: Contribution to journalArticle

Abstract

Effects of Δ8-tetrahydrocannabinol (Δ8-THC), 11-hydroxy-Δ8-THC and 11-oxo-Δ8-THC on metabolic disposition of pentobarbital in plasma, brain and liver of mice were studied. By pretreatments of mice with these cannabinoids (5 mg/kg, i.v.), the tissue concentrations of pentobarbital at 30 min after the i.p. injection (40 mg/kg) were not changed as compared with the control, although elimination of pentobarbital from the tissue in mice pretreated with cannabinoids were slower than those of the control mice. Pentobarbital concentration in brain at the time of awakening was 0.149 (control), 0.102 (Δ6-THC), 0.073 (11-hydroxy-Δ8-THC) or 0.064 μmoles/g (11-oxo-Δ8-THC). The result suggests that 11-hydroxy-Δ8-THC and 11-oxo-Δ8-THC possess a greater activity to the central nervous sytem than Δ8-THC.

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalResearch Communications in Substances of Abuse
Volume2
Issue number3
Publication statusPublished - Jan 1 1981

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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