Effects of α4β2 and α7 nicotinic acetylcholine receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats

Seiki Motoshima, Katsuya Suemaru, Youichi Kawasaki, Chunyu Jin, Hiromu Kawasaki, Yutaka Gomita, Hiroaki Araki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Acute dependence can be observed when naloxone is administered 24 h after even a single dose of morphine, and nicotine attenuates this naloxone-precipitated withdrawal syndrome. This acute dependence has been hypothesized to be associated with a dopaminergic mechanism. In the present study, the role of nicotinic acetylcholine receptor subtypes in the place aversion induced by naloxone in single-dose morphine-treated rats was investigated. Methyllycaconitine (1, 2 and 5 mg/kg), an α7 nicotinic acetylcholine receptor subtype inhibitor, significantly and dose dependently inhibited the attenuating effect of nicotine on naloxone-induced place aversion. In contrast, dihydroxy-β-erithroidine (1, 2 and 5 mg/kg), an α4β2 nicotinic acetylcholine receptor subtype inhibitor, did not have any effect on the attenuating effect of nicotine on naloxone-induced place aversion. These findings suggested that the α7 nicotinic acetylcholine receptor subtype is associated with the place aversion induced by naloxone in single-dose morphine-treated rats. Nicotinic acetylcholine receptor subtype inhibitors warrant further study as possible treatment for acute dependence.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalEuropean Journal of Pharmacology
Volume519
Issue number1-2
DOIs
Publication statusPublished - Sep 5 2005

Keywords

  • Morphine
  • Naloxone
  • Place aversion
  • α Nicotinic acetylcholine receptor subtype
  • αβ Nicotinic acetylcholine receptor subtype

ASJC Scopus subject areas

  • Pharmacology

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