Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness

Nobuaki Miyahara, Bradley J. Swanson, Katsuyuki Takeda, Christian Taube, Satoko Miyahara, Taku Kodama, Azzeddine Dakhama, Vanessa L. Ott, Erwin W. Gelfand

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Allergic asthma is a complex syndrome characterized by airway obstruction, airway inflammation and airway hyperresponsiveness (AHR). Using a mouse model of allergen-induced AHR, we previously demonstrated that CD8-deficient mice develop significantly lower AHR, eosinophilic inflammation and interleukin (IL)-13 levels in bronchoalveolar lavage fluid compared with wild-type mice. These responses were restored by adoptive transfer of antigen-primed CD8 + T cells. Previously, two distinct populations of antigen-experienced CD8+ T cells, termed effector (TEFF) and central memory (TCM) cells, have been described. After adoptive transfer into CD8-deficient mice, TEFF, but not TCM, cells restored AHR, eosinophilic inflammation and IL-13 levels. TEFF, but not TCM, cells accumulated in the lungs, and intracellular cytokine staining showed that the transferred TEFF cells were a source of IL-13. These data suggest an important role for effector CD8+ T cells in the development of AHR and airway inflammation, which may be associated with their Tc2-type cytokine production and their capacity to migrate into the lung.

Original languageEnglish
Pages (from-to)865-869
Number of pages5
JournalNature Medicine
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

Fingerprint

Respiratory Hypersensitivity
T-cells
Interleukin-13
CD8 Antigens
Inflammation
T-Lymphocytes
Adoptive Transfer
Cytokines
Lung
Bronchoalveolar Lavage Fluid
Airway Obstruction
Data storage equipment
Allergens
Asthma
Staining and Labeling
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Miyahara, N., Swanson, B. J., Takeda, K., Taube, C., Miyahara, S., Kodama, T., ... Gelfand, E. W. (2004). Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nature Medicine, 10(8), 865-869. https://doi.org/10.1038/nm1081

Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. / Miyahara, Nobuaki; Swanson, Bradley J.; Takeda, Katsuyuki; Taube, Christian; Miyahara, Satoko; Kodama, Taku; Dakhama, Azzeddine; Ott, Vanessa L.; Gelfand, Erwin W.

In: Nature Medicine, Vol. 10, No. 8, 08.2004, p. 865-869.

Research output: Contribution to journalArticle

Miyahara, N, Swanson, BJ, Takeda, K, Taube, C, Miyahara, S, Kodama, T, Dakhama, A, Ott, VL & Gelfand, EW 2004, 'Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness', Nature Medicine, vol. 10, no. 8, pp. 865-869. https://doi.org/10.1038/nm1081
Miyahara N, Swanson BJ, Takeda K, Taube C, Miyahara S, Kodama T et al. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nature Medicine. 2004 Aug;10(8):865-869. https://doi.org/10.1038/nm1081
Miyahara, Nobuaki ; Swanson, Bradley J. ; Takeda, Katsuyuki ; Taube, Christian ; Miyahara, Satoko ; Kodama, Taku ; Dakhama, Azzeddine ; Ott, Vanessa L. ; Gelfand, Erwin W. / Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. In: Nature Medicine. 2004 ; Vol. 10, No. 8. pp. 865-869.
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