[Effectiveness of tolvaptan for postoperative heart failure in a patient with combined valvular disease and pulmonary hypertension]

Taichi Kondo, Joji Hoshino, Yasuhisa Fukada, Masanori Hirota, Yu Takahashi, Tadashi Isomura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report a case of a 60-year-old man with postoperative congestive heart failure( CHF) successfully treated with tolvaptan. The patient was diagnosed with pulmonary hypertension due to mitral stenosis and regurgitation combined with tricuspid regurgitation. He underwent mitral and tricuspid valvuloplasty. His postoperative course was uneventful until CHF symptoms secondary to volume overload appeared on the 4th day. Congestion with pulmonary hypertension was treated with 0.042 μg/kg/min of intravenous human atrial natriuretic peptide (hANP). His condition improved, and on the 11th postoperative day, he was weaned off hANP;oral administration of 40 mg per day of furosemide was initiated. However, 2 days after discontinuation of intravenous hANP, CHF recurred and serum sodium decreased to 128 mEq/l. Oral tolvaptan 7.5 mg per day was added to the furosemide, and CHF and hyponatremia subsequently improved. In this case, oral tolvaptan was effective for the treatment of refractory CHF with pulmonary hypertension after cardiac surgery.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume67
Issue number2
Publication statusPublished - Feb 1 2014
Externally publishedYes

Fingerprint

Pulmonary Hypertension
Heart Failure
Atrial Natriuretic Factor
Furosemide
Tricuspid Valve Insufficiency
Hyponatremia
Mitral Valve Stenosis
Mitral Valve Insufficiency
Thoracic Surgery
Oral Administration
Sodium
tolvaptan
Serum
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Effectiveness of tolvaptan for postoperative heart failure in a patient with combined valvular disease and pulmonary hypertension]. / Kondo, Taichi; Hoshino, Joji; Fukada, Yasuhisa; Hirota, Masanori; Takahashi, Yu; Isomura, Tadashi.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 67, No. 2, 01.02.2014, p. 117-120.

Research output: Contribution to journalArticle

@article{7a0fb8a8b8f3400e9be04489690c23cd,
title = "[Effectiveness of tolvaptan for postoperative heart failure in a patient with combined valvular disease and pulmonary hypertension]",
abstract = "We report a case of a 60-year-old man with postoperative congestive heart failure( CHF) successfully treated with tolvaptan. The patient was diagnosed with pulmonary hypertension due to mitral stenosis and regurgitation combined with tricuspid regurgitation. He underwent mitral and tricuspid valvuloplasty. His postoperative course was uneventful until CHF symptoms secondary to volume overload appeared on the 4th day. Congestion with pulmonary hypertension was treated with 0.042 μg/kg/min of intravenous human atrial natriuretic peptide (hANP). His condition improved, and on the 11th postoperative day, he was weaned off hANP;oral administration of 40 mg per day of furosemide was initiated. However, 2 days after discontinuation of intravenous hANP, CHF recurred and serum sodium decreased to 128 mEq/l. Oral tolvaptan 7.5 mg per day was added to the furosemide, and CHF and hyponatremia subsequently improved. In this case, oral tolvaptan was effective for the treatment of refractory CHF with pulmonary hypertension after cardiac surgery.",
author = "Taichi Kondo and Joji Hoshino and Yasuhisa Fukada and Masanori Hirota and Yu Takahashi and Tadashi Isomura",
year = "2014",
month = "2",
day = "1",
language = "English",
volume = "67",
pages = "117--120",
journal = "Japanese Journal of Thoracic Surgery",
issn = "0021-5252",
publisher = "Nankodo Co., Ltd.",
number = "2",

}

TY - JOUR

T1 - [Effectiveness of tolvaptan for postoperative heart failure in a patient with combined valvular disease and pulmonary hypertension]

AU - Kondo, Taichi

AU - Hoshino, Joji

AU - Fukada, Yasuhisa

AU - Hirota, Masanori

AU - Takahashi, Yu

AU - Isomura, Tadashi

PY - 2014/2/1

Y1 - 2014/2/1

N2 - We report a case of a 60-year-old man with postoperative congestive heart failure( CHF) successfully treated with tolvaptan. The patient was diagnosed with pulmonary hypertension due to mitral stenosis and regurgitation combined with tricuspid regurgitation. He underwent mitral and tricuspid valvuloplasty. His postoperative course was uneventful until CHF symptoms secondary to volume overload appeared on the 4th day. Congestion with pulmonary hypertension was treated with 0.042 μg/kg/min of intravenous human atrial natriuretic peptide (hANP). His condition improved, and on the 11th postoperative day, he was weaned off hANP;oral administration of 40 mg per day of furosemide was initiated. However, 2 days after discontinuation of intravenous hANP, CHF recurred and serum sodium decreased to 128 mEq/l. Oral tolvaptan 7.5 mg per day was added to the furosemide, and CHF and hyponatremia subsequently improved. In this case, oral tolvaptan was effective for the treatment of refractory CHF with pulmonary hypertension after cardiac surgery.

AB - We report a case of a 60-year-old man with postoperative congestive heart failure( CHF) successfully treated with tolvaptan. The patient was diagnosed with pulmonary hypertension due to mitral stenosis and regurgitation combined with tricuspid regurgitation. He underwent mitral and tricuspid valvuloplasty. His postoperative course was uneventful until CHF symptoms secondary to volume overload appeared on the 4th day. Congestion with pulmonary hypertension was treated with 0.042 μg/kg/min of intravenous human atrial natriuretic peptide (hANP). His condition improved, and on the 11th postoperative day, he was weaned off hANP;oral administration of 40 mg per day of furosemide was initiated. However, 2 days after discontinuation of intravenous hANP, CHF recurred and serum sodium decreased to 128 mEq/l. Oral tolvaptan 7.5 mg per day was added to the furosemide, and CHF and hyponatremia subsequently improved. In this case, oral tolvaptan was effective for the treatment of refractory CHF with pulmonary hypertension after cardiac surgery.

UR - http://www.scopus.com/inward/record.url?scp=84925224541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925224541&partnerID=8YFLogxK

M3 - Article

C2 - 24743480

AN - SCOPUS:84925224541

VL - 67

SP - 117

EP - 120

JO - Japanese Journal of Thoracic Surgery

JF - Japanese Journal of Thoracic Surgery

SN - 0021-5252

IS - 2

ER -