Effectiveness of radiation therapy in nephrotic syndrome associated with advanced lung cancer

Yasushi Shikata, Yoshiko Hayashi, Hiroko Yamazaki, Kenichi Shikata, Hirofumi Makino

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Paraneoplastic nephrotic syndrome is rare, but occurs mostly in lung cancer. The glomerular lesion usually exhibits membranous nephropathy. Although surgical therapy has been shown to be effective, the treatment of a paraneoplastic nephrotic syndrome has always been a challenge. Currently no standard therapy has been established, if the paraneoplastic nephrotic syndrome is associated with advanced cancer with unresectable lesions. We present 2 cases having paraneoplastic nephrotic syndrome associated with advanced squamous cell carcinoma of the lung. Radiation therapy of the primary tumor effectively caused regression of the paraneoplastic nephrotic syndrome without affecting the renal function. Our results suggest that irradiation can be the first choice in the treatment of nephrotic syndrome, if the primary tumor is unresectable.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalNephron
Volume83
Issue number2
DOIs
Publication statusPublished - Oct 4 1999

Keywords

  • Membranous nephropathy
  • Paraneoplastic nephrotic syndrome
  • Radiation therapy, lung cancer

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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