Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer

Masaomi Yamane, Minoru Mizuta, Mitsumasa Kaji, Tatsuya Toyokawa, Katsuya Miyatani, Tetsunobu Udaka, Masatoshi Kubo, Nobuyuki Hosokawa, Kinichiro Suwaki, Kazutoyo Shirakawa

Research output: Contribution to journalArticle

Abstract

To determine the pathologic effectiveness of preoperative chemoradiotherapy (CRT) in patients with advanced rectal carcinoma, we reviewed clinical records of 76 patients who received preoperative pelvic radiation +/- chemotherapy. Since 2 patients refused operation and 2 died before surgery, 72 patients underwent operation with a mean delay of 19.9 days after completion of irradiation. Pathologic tumor regression grade (Grade 0-3) was determined by the amount of viable tumor versus necrosis and fibrosis. Grade 0, 1 a, 1 b, 2, and 3 (pCR) were observed in 0%, 25.0%, 38.9%, 27.8% and 2.8% of patients, respectively. The pathologic response (PR) rate was 75.0% when PR was defined as greater than grade 1 b (tumor regression more than 1/3). Downstaging was observed in 35.8% of patients, in which 5-year overall survival was significantly better than in patients without downstaging (90.0% vs. 50.1%, p

Original languageEnglish
Pages (from-to)1441-1444
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume33
Issue number10
Publication statusPublished - Oct 2006
Externally publishedYes

Fingerprint

Chemoradiotherapy
Rectal Neoplasms
Neoplasms
Fibrosis
Necrosis
Radiation
Carcinoma
Drug Therapy
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Yamane, M., Mizuta, M., Kaji, M., Toyokawa, T., Miyatani, K., Udaka, T., ... Shirakawa, K. (2006). Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer. Gan to kagaku ryoho. Cancer & chemotherapy, 33(10), 1441-1444.

Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer. / Yamane, Masaomi; Mizuta, Minoru; Kaji, Mitsumasa; Toyokawa, Tatsuya; Miyatani, Katsuya; Udaka, Tetsunobu; Kubo, Masatoshi; Hosokawa, Nobuyuki; Suwaki, Kinichiro; Shirakawa, Kazutoyo.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 33, No. 10, 10.2006, p. 1441-1444.

Research output: Contribution to journalArticle

Yamane, M, Mizuta, M, Kaji, M, Toyokawa, T, Miyatani, K, Udaka, T, Kubo, M, Hosokawa, N, Suwaki, K & Shirakawa, K 2006, 'Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 33, no. 10, pp. 1441-1444.
Yamane M, Mizuta M, Kaji M, Toyokawa T, Miyatani K, Udaka T et al. Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer. Gan to kagaku ryoho. Cancer & chemotherapy. 2006 Oct;33(10):1441-1444.
Yamane, Masaomi ; Mizuta, Minoru ; Kaji, Mitsumasa ; Toyokawa, Tatsuya ; Miyatani, Katsuya ; Udaka, Tetsunobu ; Kubo, Masatoshi ; Hosokawa, Nobuyuki ; Suwaki, Kinichiro ; Shirakawa, Kazutoyo. / Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2006 ; Vol. 33, No. 10. pp. 1441-1444.
@article{5c74bfd14b6e4c0ab8db7c0f9f8970dc,
title = "Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer",
abstract = "To determine the pathologic effectiveness of preoperative chemoradiotherapy (CRT) in patients with advanced rectal carcinoma, we reviewed clinical records of 76 patients who received preoperative pelvic radiation +/- chemotherapy. Since 2 patients refused operation and 2 died before surgery, 72 patients underwent operation with a mean delay of 19.9 days after completion of irradiation. Pathologic tumor regression grade (Grade 0-3) was determined by the amount of viable tumor versus necrosis and fibrosis. Grade 0, 1 a, 1 b, 2, and 3 (pCR) were observed in 0{\%}, 25.0{\%}, 38.9{\%}, 27.8{\%} and 2.8{\%} of patients, respectively. The pathologic response (PR) rate was 75.0{\%} when PR was defined as greater than grade 1 b (tumor regression more than 1/3). Downstaging was observed in 35.8{\%} of patients, in which 5-year overall survival was significantly better than in patients without downstaging (90.0{\%} vs. 50.1{\%}, p",
author = "Masaomi Yamane and Minoru Mizuta and Mitsumasa Kaji and Tatsuya Toyokawa and Katsuya Miyatani and Tetsunobu Udaka and Masatoshi Kubo and Nobuyuki Hosokawa and Kinichiro Suwaki and Kazutoyo Shirakawa",
year = "2006",
month = "10",
language = "English",
volume = "33",
pages = "1441--1444",
journal = "Japanese Journal of Cancer and Chemotherapy",
issn = "0385-0684",
publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",
number = "10",

}

TY - JOUR

T1 - Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer

AU - Yamane, Masaomi

AU - Mizuta, Minoru

AU - Kaji, Mitsumasa

AU - Toyokawa, Tatsuya

AU - Miyatani, Katsuya

AU - Udaka, Tetsunobu

AU - Kubo, Masatoshi

AU - Hosokawa, Nobuyuki

AU - Suwaki, Kinichiro

AU - Shirakawa, Kazutoyo

PY - 2006/10

Y1 - 2006/10

N2 - To determine the pathologic effectiveness of preoperative chemoradiotherapy (CRT) in patients with advanced rectal carcinoma, we reviewed clinical records of 76 patients who received preoperative pelvic radiation +/- chemotherapy. Since 2 patients refused operation and 2 died before surgery, 72 patients underwent operation with a mean delay of 19.9 days after completion of irradiation. Pathologic tumor regression grade (Grade 0-3) was determined by the amount of viable tumor versus necrosis and fibrosis. Grade 0, 1 a, 1 b, 2, and 3 (pCR) were observed in 0%, 25.0%, 38.9%, 27.8% and 2.8% of patients, respectively. The pathologic response (PR) rate was 75.0% when PR was defined as greater than grade 1 b (tumor regression more than 1/3). Downstaging was observed in 35.8% of patients, in which 5-year overall survival was significantly better than in patients without downstaging (90.0% vs. 50.1%, p

AB - To determine the pathologic effectiveness of preoperative chemoradiotherapy (CRT) in patients with advanced rectal carcinoma, we reviewed clinical records of 76 patients who received preoperative pelvic radiation +/- chemotherapy. Since 2 patients refused operation and 2 died before surgery, 72 patients underwent operation with a mean delay of 19.9 days after completion of irradiation. Pathologic tumor regression grade (Grade 0-3) was determined by the amount of viable tumor versus necrosis and fibrosis. Grade 0, 1 a, 1 b, 2, and 3 (pCR) were observed in 0%, 25.0%, 38.9%, 27.8% and 2.8% of patients, respectively. The pathologic response (PR) rate was 75.0% when PR was defined as greater than grade 1 b (tumor regression more than 1/3). Downstaging was observed in 35.8% of patients, in which 5-year overall survival was significantly better than in patients without downstaging (90.0% vs. 50.1%, p

UR - http://www.scopus.com/inward/record.url?scp=33750694259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750694259&partnerID=8YFLogxK

M3 - Article

C2 - 17033234

AN - SCOPUS:33750694259

VL - 33

SP - 1441

EP - 1444

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

IS - 10

ER -