Effectiveness of 3 ways method in intra-arterial infusion chemotherapy for advanced or recurrent cervical cancer with or without radiotherapy

Y. Kaneyasu, M. Kita, K. Katsui, M. Kono, N. Kojima, K. Himei, M. Isobe, K. Karasawa, J. Toda, E. Yamanouchi, T. Okawa

Research output: Contribution to journalArticle

Abstract

We analyzed 58 cases of advanced or recurrent cervical cancer treated with intra-arterial infusion chemotherapy (IAIC) with or without radiotherapy. Two separate IAIC regimens were administered since 1985: group I consisted of 5-FU + MMC +/- ADR (30 patients) and group II consisted of CDDP + MMC +/- 5-FU (28 patients). The tip of a catheter was placed in the bifurcation of the abdominal aorta (1 way method: 45 patients regimen II: 15) between 1977-1984. We have used selective catheterization (2 ways method: 9) since 1995 in order to get good drug distribution. However we experienced grade 4 toxic effect of cutaneous and pain with this method, so we have used a 3 ways method (4 patients) since 1998. The two-year survival rete was 60% with the 1 way method, and 67% with the 2 ways method and regimen II. Severe adverse effects (grade 3 + 4) were found in 53, 56, 0%, respectively, by each of the three methods (1, 2, 3 ways) hematologically, 13, 22, 0% in gastrointestinally, 0, 44, 0% in cutaneously and 0, 56, 0% in pain or neurotoxicity. These data suggest that IAIC by the 3 ways method is a useful treatment for advanced or recurrent cervical cancer. However, one should check the blood flow distribution periodically, and control concentration of drugs.

Original languageEnglish
Pages (from-to)1860-1863
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume26
Issue number12
Publication statusPublished - Oct 1999
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kaneyasu, Y., Kita, M., Katsui, K., Kono, M., Kojima, N., Himei, K., Isobe, M., Karasawa, K., Toda, J., Yamanouchi, E., & Okawa, T. (1999). Effectiveness of 3 ways method in intra-arterial infusion chemotherapy for advanced or recurrent cervical cancer with or without radiotherapy. Gan to kagaku ryoho. Cancer & chemotherapy, 26(12), 1860-1863.