Effective productions of plant secondary metabolites having antitumor activity by plant cell and tissue cultures

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2 Citations (Scopus)

Abstract

Methods for the effective production of plant secondary metabolites with antitumor activity using plant cell and tissue cultures were developed. The factors in tannin productivity were investigated using culture strains producing different types of hydrolyzable tannins, i.e., gallotannins (mixture of galloylglucoses), ellagi-, and dehydroellagitannins. Production of ellagi- and dehydroellagitannins was affected by the concentrations and ratio of nitrogen sources in the medium. The formation of oligomeric ellagitannins in shoots of Oenothera tetraptera was correlated with the differentiation of tissues. Cultured cells of Eriobotrya japonica producing ursane- and oleanane-type triterpenes with antitumor activities were also established.

Original languageEnglish
Pages (from-to)499-507
Number of pages9
JournalYakugaku Zasshi
Volume125
Issue number6
DOIs
Publication statusPublished - Jul 6 2005

Keywords

  • Antitumor activity
  • Hydrolzsable tannin
  • Plant tissue culture
  • Triterpene

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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