Effective production of dehydro cyclic dipeptide albonoursin exhibiting pronuclear fusion inhibitory activity. I. Taxonomy and fermentation

Hiroshi Kanzaki, Daisuke Imura, Reiko Sashida, Akio Kobayashi, Kazuyoshi Kawazu

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11 Citations (Scopus)

Abstract

Strain KO-23, an actinomycete producing albonoursin as well as streptopyrone, was identified as Streptomyces albulus by morphological and biochemical studies. Fermentation conditions for albonoursin, a dehydro cyclic dipeptide exhibiting a pronounced inhibitory activity toward pronuclear fusion of sea urchin eggs, were optimized. Under the optimum conditions, the actinomycete produced 16 mg/liter of albonoursin, 30 times higher than that in the original culture. The cells cultivated under these conditions highly express biosynthetic enzymes for albonoursin, and thus are available for biosynthetic studies of dehydro cyclic peptides.

Original languageEnglish
Pages (from-to)1017-1022
Number of pages6
JournalJournal of Antibiotics
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 1999

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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