Effect on the donor lungs of using abdominal normothermic regional perfusion in controlled donation after circulatory death

Shin Tanaka, Jose Luis Campo Cañaveral De La Cruz, Silvana Crowley Carrasco, Alejandra Romero Román, Lucas Hoyos Mejía, Jose Manuel Naranjogómez, Mar Córdoba Peláez, Álvaro Sánchez Calle, Mariana Gil Barturen, Marina Pérez Redondo, Christian García Fadul, Andrés Varela De Ugarte, David Gómez-De-Antonio

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objectives: Controlled donation after circulatory death (cDCD) donors are becoming a common source of organs for transplantation globally. However, the graft survival rate of cDCD abdominal organs is inferior to that of organs from brain-dead donors. The rapid retrieval (RR) technique is used by most donor organ procurement teams. The abdominal normothermic regional perfusion (A-NRP) technique has been implemented to minimize warm ischaemic damage to the abdominal organs. However, there is limited information on the effect of A-NRP on the quality of the donor lungs. This study aimed to compare lung transplantation outcomes using lungs procured from cDCD donors using the A-NRP and abdominal RR techniques. Methods: A single-centre retrospective analysis of consecutive transplant recipients of cDCD lungs from June 2013 to December 2019 was performed. The recipients were divided into 2 cohorts according to the abdominal procurement technique used. The recipient and donor characteristics (age, sex, cause of brain injury, warm ischaemic time, diagnosis, lung allocation score and other factors), incidence of primary graft dysfunction and early survival were monitored. Results: Twenty-eight consecutive lung transplantation recipients were identified (median age 59 years; 61% male); 14 recipients received lungs using the A-NRP and 14 using abdominal RR for abdominal organ retrieval. There were no significant differences in the baseline characteristics, primary graft dysfunction (P = 0.70), hospital mortality (P = 1.0) and 1-year survival rate (P = 1.0) between the 2 groups. Conclusions: No difference was observed in lung transplantation outcomes irrespective of the abdominal organ procurement technique used (A-NRP or abdominal RR).

Original languageEnglish
Pages (from-to)359-366
Number of pages8
JournalEuropean Journal of Cardio-Thoracic Surgery
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 1 2021
Externally publishedYes

Keywords

  • Abdominal normothermic regional perfusion
  • Controlled donation after circulatory death
  • Lung transplantation

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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