Effect of vitamin E on alloxan-induced mouse diabetes

Wakana Kamimura, Wakana Doi, Kazunori Takemoto, Kohji Ishihara, Da Hong Wang, Hitoshi Sugiyama, Sen ichi Oda, Noriyoshi Masuoka

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14 Citations (Scopus)

Abstract

Objectives: Alloxan generates hydrogen peroxide in the body, and a small amount of alloxan administered to acatalasemic mice results in diabetes. D-α-Tocopherol (vitamin E) is an antioxidant which helps prevent excess oxidation in the body. In this study, we examined the effect of vitamin E on diabetes caused by alloxan administration in mice. Methods: Mice were maintained on a vitamin E-deprived diet and supplemented diet, respectively, for 14. weeks. Alloxan was then intraperitoneally administered, and blood glucose, glucose tolerance and the insulin level in mouse blood were examined. Results: Hyperglycemia was observed in the mice maintained on the vitamin E-deprived diet. The incidence of hyperglycemia in the mice maintained on the vitamin E-deprived diet was significantly higher than that in the mice maintained on the supplemented diet. The abnormal glucose metabolism caused by alloxan administration was ameliorated by the vitamin E-supplemented diet. Conclusions: It is deduced that vitamin E can prevent a decrease of insulin concentration in the blood in this mouse model.

Original languageEnglish
Pages (from-to)795-798
Number of pages4
JournalClinical Biochemistry
Volume46
Issue number9
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Acatalasemia
  • Alloxan
  • Catalase
  • Diabetes
  • Insulin
  • Oxidative stress
  • Vitamin E

ASJC Scopus subject areas

  • Clinical Biochemistry

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  • Cite this

    Kamimura, W., Doi, W., Takemoto, K., Ishihara, K., Wang, D. H., Sugiyama, H., Oda, S. I., & Masuoka, N. (2013). Effect of vitamin E on alloxan-induced mouse diabetes. Clinical Biochemistry, 46(9), 795-798. https://doi.org/10.1016/j.clinbiochem.2013.02.016