Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats

Shin Tokunaga, Yasuhiro Takeda, Tsuyoshi Niimoto, Norihisa Nishida, Toshihiro Kubo, Tohru Ohno, Youichi Matsuura, Yuzo Kawahara, Kazuaki Shinomiya, Chiaki Kamei

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Abstract

In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2007

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Keywords

  • Insomnia
  • Sleep latency
  • Sleep quality
  • Sleep-disturbed model
  • Valerian extract
  • Valerian extract preparation (BIM)

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Tokunaga, S., Takeda, Y., Niimoto, T., Nishida, N., Kubo, T., Ohno, T., Matsuura, Y., Kawahara, Y., Shinomiya, K., & Kamei, C. (2007). Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. Biological and Pharmaceutical Bulletin, 30(2), 363-366. https://doi.org/10.1248/bpb.30.363