Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats

Shin Tokunaga, Yasuhiro Takeda, Tsuyoshi Niimoto, Norihisa Nishida, Toshihiro Kubo, Tohru Ohno, Youichi Matsuura, Yuzo Kawahara, Kazuaki Shinomiya, Chiaki Kamei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2007

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Valerian
Sleep
Wakefulness
Rhodiola
Herbal Medicine
REM Sleep
Eye Movements

Keywords

  • Insomnia
  • Sleep latency
  • Sleep quality
  • Sleep-disturbed model
  • Valerian extract
  • Valerian extract preparation (BIM)

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Tokunaga, S., Takeda, Y., Niimoto, T., Nishida, N., Kubo, T., Ohno, T., ... Kamei, C. (2007). Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. Biological and Pharmaceutical Bulletin, 30(2), 363-366. https://doi.org/10.1248/bpb.30.363

Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. / Tokunaga, Shin; Takeda, Yasuhiro; Niimoto, Tsuyoshi; Nishida, Norihisa; Kubo, Toshihiro; Ohno, Tohru; Matsuura, Youichi; Kawahara, Yuzo; Shinomiya, Kazuaki; Kamei, Chiaki.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 2, 02.2007, p. 363-366.

Research output: Contribution to journalArticle

Tokunaga, S, Takeda, Y, Niimoto, T, Nishida, N, Kubo, T, Ohno, T, Matsuura, Y, Kawahara, Y, Shinomiya, K & Kamei, C 2007, 'Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats', Biological and Pharmaceutical Bulletin, vol. 30, no. 2, pp. 363-366. https://doi.org/10.1248/bpb.30.363
Tokunaga, Shin ; Takeda, Yasuhiro ; Niimoto, Tsuyoshi ; Nishida, Norihisa ; Kubo, Toshihiro ; Ohno, Tohru ; Matsuura, Youichi ; Kawahara, Yuzo ; Shinomiya, Kazuaki ; Kamei, Chiaki. / Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. In: Biological and Pharmaceutical Bulletin. 2007 ; Vol. 30, No. 2. pp. 363-366.
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