Abstract
In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
Original language | English |
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Pages (from-to) | 363-366 |
Number of pages | 4 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 30 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2007 |
Keywords
- Insomnia
- Sleep latency
- Sleep quality
- Sleep-disturbed model
- Valerian extract
- Valerian extract preparation (BIM)
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science