Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats

Shin Tokunaga; Yasuhiro Takeda; Tsuyoshi Niimoto; Norihisa Nishida; Toshihiro Kubo; Tohru Ohno; Youichi Matsuura; Yuzo Kawahara; Kazuaki Shinomiya; Chiaki Kamei

doi:10.1248/bpb.30.363

Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats

Shin Tokunaga, Yasuhiro Takeda, Tsuyoshi Niimoto, Norihisa Nishida, Toshihiro Kubo, Tohru Ohno, Youichi Matsuura, Yuzo Kawahara, Kazuaki Shinomiya, Chiaki Kamei

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

Original language	English
Pages (from-to)	363-366
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	30
Issue number	2
DOIs	https://doi.org/10.1248/bpb.30.363
Publication status	Published - Feb 2007

Keywords

Insomnia
Sleep latency
Sleep quality
Sleep-disturbed model
Valerian extract
Valerian extract preparation (BIM)

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.30.363

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abstract = "In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.",

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author = "Shin Tokunaga and Yasuhiro Takeda and Tsuyoshi Niimoto and Norihisa Nishida and Toshihiro Kubo and Tohru Ohno and Youichi Matsuura and Yuzo Kawahara and Kazuaki Shinomiya and Chiaki Kamei",

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AU - Nishida, Norihisa

AU - Kubo, Toshihiro

AU - Ohno, Tohru

AU - Matsuura, Youichi

AU - Kawahara, Yuzo

AU - Shinomiya, Kazuaki

AU - Kamei, Chiaki

PY - 2007/2

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N2 - In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

AB - In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

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Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats

Abstract

Keywords

ASJC Scopus subject areas

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