Abstract
In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
| Original language | English |
|---|---|
| Pages (from-to) | 363-366 |
| Number of pages | 4 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2007 |
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Keywords
- Insomnia
- Sleep latency
- Sleep quality
- Sleep-disturbed model
- Valerian extract
- Valerian extract preparation (BIM)
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. / Tokunaga, Shin; Takeda, Yasuhiro; Niimoto, Tsuyoshi; Nishida, Norihisa; Kubo, Toshihiro; Ohno, Tohru; Matsuura, Youichi; Kawahara, Yuzo; Shinomiya, Kazuaki; Kamei, Chiaki.
In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 2, 02.2007, p. 363-366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats
AU - Tokunaga, Shin
AU - Takeda, Yasuhiro
AU - Niimoto, Tsuyoshi
AU - Nishida, Norihisa
AU - Kubo, Toshihiro
AU - Ohno, Tohru
AU - Matsuura, Youichi
AU - Kawahara, Yuzo
AU - Shinomiya, Kazuaki
AU - Kamei, Chiaki
PY - 2007/2
Y1 - 2007/2
N2 - In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
AB - In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
KW - Insomnia
KW - Sleep latency
KW - Sleep quality
KW - Sleep-disturbed model
KW - Valerian extract
KW - Valerian extract preparation (BIM)
UR - http://www.scopus.com/inward/record.url?scp=33847000538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847000538&partnerID=8YFLogxK
U2 - 10.1248/bpb.30.363
DO - 10.1248/bpb.30.363
M3 - Article
C2 - 17268081
AN - SCOPUS:33847000538
VL - 30
SP - 363
EP - 366
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 2
ER -