Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients

Hirokazu Watanabe, Hideo Kunitoh, Seiichiro Yamamoto, Shin Kawasaki, Akira Inoue, Katsuyuki Hotta, Kazu Shiomi, Masahiko Kusumoto, Kazuro Sugimura, Nagahiro Saijo

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Abstract

We evaluated interobserver reproducibility for the response evaluation criteria in solid tumors (RECIST) guidelines and the influence of minimum lesion size (MLS) on reproducibility. The 110 consecutive patients with non-small cell lung cancer were treated with platinum-based chemotherapy. Five observers measured target lesions according to both the World Health Organization (WHO) criteria and RECIST. The percentage changes for unidimensional measurements (UD; RECIST type) and bidimensional measurements (BD; WHO type) were calculated for each patient. Interobserver reproducibility among five observers, that is 10 pairs, was expressed as the Spearman's correlation coefficient for the percentage changes, the proportion of agreement and the kappa statistics for response categories. The same analysis was carried out using MLS. BD was more reproducible than UD (Spearman rank correlation coefficient, 0.84 vs 0.81; proportion of agreement, 84.4% vs 82.5%; kappa value, 0.69 vs 0.61). When MLS was applied to UD, eligible cases decreased by 6.4% and the number of target lesions by 44.6%, whereas interobserver reproducibility for UD improved (Spearman rank correlation coefficient, 0.81-0.84; proportion of agreement, 82.5-84.2%; kappa value, 0.61-0.65). The introduction of MLS to UD could also improve intercriteria reproducibility between WHO and RECIST. It is important to apply the MLS when using RECIST for the comparable interobserver reproducibility attained with WHO.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalCancer Science
Volume97
Issue number3
DOIs
Publication statusPublished - Mar 2006
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Guidelines
Nonparametric Statistics
Platinum
Response Evaluation Criteria in Solid Tumors
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients. / Watanabe, Hirokazu; Kunitoh, Hideo; Yamamoto, Seiichiro; Kawasaki, Shin; Inoue, Akira; Hotta, Katsuyuki; Shiomi, Kazu; Kusumoto, Masahiko; Sugimura, Kazuro; Saijo, Nagahiro.

In: Cancer Science, Vol. 97, No. 3, 03.2006, p. 214-218.

Research output: Contribution to journalArticle

Watanabe, H, Kunitoh, H, Yamamoto, S, Kawasaki, S, Inoue, A, Hotta, K, Shiomi, K, Kusumoto, M, Sugimura, K & Saijo, N 2006, 'Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients', Cancer Science, vol. 97, no. 3, pp. 214-218. https://doi.org/10.1111/j.1349-7006.2006.00157.x
Watanabe, Hirokazu ; Kunitoh, Hideo ; Yamamoto, Seiichiro ; Kawasaki, Shin ; Inoue, Akira ; Hotta, Katsuyuki ; Shiomi, Kazu ; Kusumoto, Masahiko ; Sugimura, Kazuro ; Saijo, Nagahiro. / Effect of the introduction of minimum lesion size on interobserver reproducibility using RECIST guidelines in non-small cell lung cancer patients. In: Cancer Science. 2006 ; Vol. 97, No. 3. pp. 214-218.
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