Effect of tandospirone on sleep latency in rats placed on a grid suspended over water

Yoshiaki Utsu, Kazuaki Shinomiya, Shin Tokunaga, Asae Ohmori, Chiaki Kamei

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present study was performed to examine the effect of tandospirone on sleep latency in a new insomnia animal model by placing rats on a grid suspended over water. For investigating the mechanism of tandospirone, the effect of tandospirone on sleep latency was also studied using rats that were depleted with neuronal serotonin (5-HT) after p-chlorophenylalanine administration. Tandospirone caused a shortening of sleep latency dose-dependently, and a significant effect was observed at 20 mg/kg, p.o. or more. A shortening of sleep latency was observed by administration of p-chlorophenylalanine (300 mg/kg, i.p.) for 2 days. On the other hand, tandospirone exerted no potentiating effect on the shortening of sleep latency induced by p-chlorophenylalanine. From these findings, a shortening of sleep latency induced by tandospirone may occur through the pre-synaptic 5-HT1A receptors in rats.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalJournal of Pharmacological Sciences
Volume105
Issue number1
DOIs
Publication statusPublished - Sep 28 2007

Keywords

  • 5-HT receptor
  • Antianxiety
  • Sleep disturbed model
  • Sleep latency
  • Tandospirone

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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