Effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells

Andrea P. Rodríguez, María A. Sánchez, Miho Inoue, Betiana Felice, Hitoshi Nagatsuka, Rossana E. Madrid, Carmelo Felice, Hidetsugu Tsujigiwa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get ‘‘calcium titanate with calcium carbonate’’ (CaTiO3–CaCO3). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that Ca-TiO3–CaCO3 material sintered during 30 min, has better influ-ence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO3-CaCO3 sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary find-ings indicate that CaTiO3–CaCO3 could play a more dominant and favorable effect on cell response when sintered for 30 minutes.

Original languageEnglish
Title of host publicationVI Latin American Congress on Biomedical Engineering, CLAIB 2014
EditorsAriel Braidot, Alejandro Hadad
PublisherSpringer Verlag
Pages159-162
Number of pages4
ISBN (Electronic)9783319131160
DOIs
Publication statusPublished - 2015
Event6th Latin American Congress on Biomedical Engineering, CLAIB 2014 - Paraná, Argentina
Duration: Oct 29 2014Oct 31 2014

Publication series

NameIFMBE Proceedings
Volume49
ISSN (Print)1680-0737

Other

Other6th Latin American Congress on Biomedical Engineering, CLAIB 2014
CountryArgentina
CityParaná
Period10/29/1410/31/14

Keywords

  • Calcium titanate
  • Carbonate
  • Cell culture
  • Osteoblast
  • Particles

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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    Rodríguez, A. P., Sánchez, M. A., Inoue, M., Felice, B., Nagatsuka, H., Madrid, R. E., Felice, C., & Tsujigiwa, H. (2015). Effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells. In A. Braidot, & A. Hadad (Eds.), VI Latin American Congress on Biomedical Engineering, CLAIB 2014 (pp. 159-162). (IFMBE Proceedings; Vol. 49). Springer Verlag. https://doi.org/10.1007/978-3-319-13117-7_42