@inproceedings{ed4d9d8886954bdab8770971c5b423d7,
title = "Effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells",
abstract = "In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get {\textquoteleft}{\textquoteleft}calcium titanate with calcium carbonate{\textquoteright}{\textquoteright} (CaTiO3–CaCO3). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that Ca-TiO3–CaCO3 material sintered during 30 min, has better influ-ence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO3-CaCO3 sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary find-ings indicate that CaTiO3–CaCO3 could play a more dominant and favorable effect on cell response when sintered for 30 minutes.",
keywords = "Calcium titanate, Carbonate, Cell culture, Osteoblast, Particles",
author = "Rodr{\'i}guez, {Andrea P.} and S{\'a}nchez, {Mar{\'i}a A.} and Miho Inoue and Betiana Felice and Hitoshi Nagatsuka and Madrid, {Rossana E.} and Carmelo Felice and Hidetsugu Tsujigiwa",
year = "2015",
doi = "10.1007/978-3-319-13117-7_42",
language = "English",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
pages = "159--162",
editor = "Ariel Braidot and Alejandro Hadad",
booktitle = "VI Latin American Congress on Biomedical Engineering, CLAIB 2014",
note = "6th Latin American Congress on Biomedical Engineering, CLAIB 2014 ; Conference date: 29-10-2014 Through 31-10-2014",
}