Effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells

Andrea P. Rodríguez; María A. Sánchez; Miho Inoue; Betiana Felice; Hitoshi Nagatsuka; Rossana E. Madrid; Carmelo Felice; Hidetsugu Tsujigiwa

doi:10.1007/978-3-319-13117-7_42

Effect of sintering time of CaTiO₃–CaCO₃ in osteoblastic response of KUSA/A1 cells

Andrea P. Rodríguez, María A. Sánchez, Miho Inoue, Betiana Felice, Hitoshi Nagatsuka, Rossana E. Madrid, Carmelo Felice, Hidetsugu Tsujigiwa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get ‘‘calcium titanate with calcium carbonate’’ (CaTiO₃–CaCO₃). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO₃–CaCO₃ in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that Ca-TiO₃–CaCO³ material sintered during 30 min, has better influ-ence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO₃-CaCO₃ sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary find-ings indicate that CaTiO₃–CaCO₃ could play a more dominant and favorable effect on cell response when sintered for 30 minutes.

Original language	English
Title of host publication	VI Latin American Congress on Biomedical Engineering, CLAIB 2014
Editors	Ariel Braidot, Alejandro Hadad
Publisher	Springer Verlag
Pages	159-162
Number of pages	4
ISBN (Electronic)	9783319131160
DOIs	https://doi.org/10.1007/978-3-319-13117-7_42
Publication status	Published - 2015
Event	6th Latin American Congress on Biomedical Engineering, CLAIB 2014 - Paraná, Argentina Duration: Oct 29 2014 → Oct 31 2014

Publication series

Name	IFMBE Proceedings
Volume	49
ISSN (Print)	1680-0737

Other

Other	6th Latin American Congress on Biomedical Engineering, CLAIB 2014
Country	Argentina
City	Paraná
Period	10/29/14 → 10/31/14

Keywords

Calcium titanate
Carbonate
Cell culture
Osteoblast
Particles

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

Access to Document

10.1007/978-3-319-13117-7_42

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Rodríguez, A. P., Sánchez, M. A., Inoue, M., Felice, B., Nagatsuka, H., Madrid, R. E., Felice, C., & Tsujigiwa, H. (2015). Effect of sintering time of CaTiO₃–CaCO₃ in osteoblastic response of KUSA/A1 cells. In A. Braidot, & A. Hadad (Eds.), VI Latin American Congress on Biomedical Engineering, CLAIB 2014 (pp. 159-162). (IFMBE Proceedings; Vol. 49). Springer Verlag. https://doi.org/10.1007/978-3-319-13117-7_42

Effect of sintering time of CaTiO₃–CaCO₃ in osteoblastic response of KUSA/A1 cells. / Rodríguez, Andrea P.; Sánchez, María A.; Inoue, Miho; Felice, Betiana; Nagatsuka, Hitoshi; Madrid, Rossana E.; Felice, Carmelo; Tsujigiwa, Hidetsugu.

VI Latin American Congress on Biomedical Engineering, CLAIB 2014. ed. / Ariel Braidot; Alejandro Hadad. Springer Verlag, 2015. p. 159-162 (IFMBE Proceedings; Vol. 49).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Rodríguez, AP, Sánchez, MA, Inoue, M, Felice, B, Nagatsuka, H, Madrid, RE, Felice, C & Tsujigiwa, H 2015, Effect of sintering time of CaTiO₃–CaCO₃ in osteoblastic response of KUSA/A1 cells. in A Braidot & A Hadad (eds), VI Latin American Congress on Biomedical Engineering, CLAIB 2014. IFMBE Proceedings, vol. 49, Springer Verlag, pp. 159-162, 6th Latin American Congress on Biomedical Engineering, CLAIB 2014, Paraná, Argentina, 10/29/14. https://doi.org/10.1007/978-3-319-13117-7_42

Rodríguez, Andrea P. ; Sánchez, María A. ; Inoue, Miho ; Felice, Betiana ; Nagatsuka, Hitoshi ; Madrid, Rossana E. ; Felice, Carmelo ; Tsujigiwa, Hidetsugu. / Effect of sintering time of CaTiO₃–CaCO₃ in osteoblastic response of KUSA/A1 cells. VI Latin American Congress on Biomedical Engineering, CLAIB 2014. editor / Ariel Braidot ; Alejandro Hadad. Springer Verlag, 2015. pp. 159-162 (IFMBE Proceedings).

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AB - In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get ‘‘calcium titanate with calcium carbonate’’ (CaTiO3–CaCO3). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that Ca-TiO3–CaCO3 material sintered during 30 min, has better influ-ence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO3-CaCO3 sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary find-ings indicate that CaTiO3–CaCO3 could play a more dominant and favorable effect on cell response when sintered for 30 minutes.

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