Effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells

Andrea P. Rodríguez, María A. Sánchez, Miho Inoue, Betiana Felice, Hitoshi Nagatsuka, Rossana E. Madrid, Carmelo Felice, Hidetsugu Tsujigiwa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In recent years, calcium titanate (CaTiO3) and carbon-containing materials have gained much attention in a number of biomedical material researches. To maximize the advantages of both materials, we developed a novel alkoxide method to get ‘‘calcium titanate with calcium carbonate’’ (CaTiO3–CaCO3). Thus, our previous result indicated that calcium carbonate could play a key role in the cell response of CaTiO3 material. In the present study we evaluated the effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells. We examined the material characterization as well as cellular proliferation and mineralization of KUSA/A1 cells cultured with the materials. The results showed that Ca-TiO3–CaCO3 material sintered during 30 min, has better influ-ence on the bone marrow stromal cells for their proliferation and mineralization compared to CaTiO3-CaCO3 sintered at 2 and 10 h. These results suggest that sintering time could be directly related to the amount of carbon within CaCO3 being crucial in cell response. In conclusion, our preliminary find-ings indicate that CaTiO3–CaCO3 could play a more dominant and favorable effect on cell response when sintered for 30 minutes.

Original languageEnglish
Title of host publicationVI Latin American Congress on Biomedical Engineering, CLAIB 2014
PublisherSpringer Verlag
Pages159-162
Number of pages4
Volume49
ISBN (Print)9783319131160
DOIs
Publication statusPublished - 2015
Event6th Latin American Congress on Biomedical Engineering, CLAIB 2014 - Paraná, Argentina
Duration: Oct 29 2014Oct 31 2014

Other

Other6th Latin American Congress on Biomedical Engineering, CLAIB 2014
CountryArgentina
CityParaná
Period10/29/1410/31/14

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Keywords

  • Calcium titanate
  • Carbonate
  • Cell culture
  • Osteoblast
  • Particles

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Rodríguez, A. P., Sánchez, M. A., Inoue, M., Felice, B., Nagatsuka, H., Madrid, R. E., Felice, C., & Tsujigiwa, H. (2015). Effect of sintering time of CaTiO3–CaCO3 in osteoblastic response of KUSA/A1 cells. In VI Latin American Congress on Biomedical Engineering, CLAIB 2014 (Vol. 49, pp. 159-162). Springer Verlag. https://doi.org/10.1007/978-3-319-13117-7_42