Effect of santalol on the sleep-wake cycle in sleep-disturbed rats

Asae Ohmori, Kazuaki Shinomiya, Yoshiaki Utsu, Shin Tokunaga, Yasuyuki Hasegawa, Chiaki Kamei

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Sandalwood oil is widely used in aromatherapy for alleviating various symptoms. Santalol, a major component of sandalwood oil, has been reported to have central nervous system depressant effects such as sedation. In the present study, we investigated the effect of santalol on the sleep-wake cycle in sleep-disturbed rats. When inhaled at a concentration of 5 × 10 -2 ppm, santalol caused a significant decrease in total waking time and an increase in total non-rapid eye movement (NREM) sleep time. In order to clarify the mechanism of action, olfactory hypofunction was caused in rats by intranasal application of 5% zinc sulfate solution, and thereafter the effects of inhalation of fragrances were evaluated. In this study, it was found that the impairment of the olfactory system showed no significant effect on the changes in sleep parameters induced by santalol. This result suggests that santalol may act via the circulatory system rather than the olfactory system. That is, santalol is thought to be absorbed into the blood through the respiratory mucosa, and then exert its action. From these results, it is concluded that santalol may be useful in patients having difficulty maintaining sleep without being affected by individual differences in perfume-related preference.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalJapanese Journal of Neuropsychopharmacology
Volume27
Issue number4
Publication statusPublished - Aug 2007

Fingerprint

Sleep
Aromatherapy
Perfume
Central Nervous System Depressants
Zinc Sulfate
Respiratory Mucosa
Eye Movements
Cardiovascular System
santalol
Individuality
Inhalation
sandalwood oil

Keywords

  • Inhalation
  • Santalol
  • Sleep-disturbed rats
  • Sleep-wake cycle

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Ohmori, A., Shinomiya, K., Utsu, Y., Tokunaga, S., Hasegawa, Y., & Kamei, C. (2007). Effect of santalol on the sleep-wake cycle in sleep-disturbed rats. Japanese Journal of Neuropsychopharmacology, 27(4), 167-171.

Effect of santalol on the sleep-wake cycle in sleep-disturbed rats. / Ohmori, Asae; Shinomiya, Kazuaki; Utsu, Yoshiaki; Tokunaga, Shin; Hasegawa, Yasuyuki; Kamei, Chiaki.

In: Japanese Journal of Neuropsychopharmacology, Vol. 27, No. 4, 08.2007, p. 167-171.

Research output: Contribution to journalArticle

Ohmori, A, Shinomiya, K, Utsu, Y, Tokunaga, S, Hasegawa, Y & Kamei, C 2007, 'Effect of santalol on the sleep-wake cycle in sleep-disturbed rats', Japanese Journal of Neuropsychopharmacology, vol. 27, no. 4, pp. 167-171.
Ohmori A, Shinomiya K, Utsu Y, Tokunaga S, Hasegawa Y, Kamei C. Effect of santalol on the sleep-wake cycle in sleep-disturbed rats. Japanese Journal of Neuropsychopharmacology. 2007 Aug;27(4):167-171.
Ohmori, Asae ; Shinomiya, Kazuaki ; Utsu, Yoshiaki ; Tokunaga, Shin ; Hasegawa, Yasuyuki ; Kamei, Chiaki. / Effect of santalol on the sleep-wake cycle in sleep-disturbed rats. In: Japanese Journal of Neuropsychopharmacology. 2007 ; Vol. 27, No. 4. pp. 167-171.
@article{59b586aa8988456d9f14753a1a730ef8,
title = "Effect of santalol on the sleep-wake cycle in sleep-disturbed rats",
abstract = "Sandalwood oil is widely used in aromatherapy for alleviating various symptoms. Santalol, a major component of sandalwood oil, has been reported to have central nervous system depressant effects such as sedation. In the present study, we investigated the effect of santalol on the sleep-wake cycle in sleep-disturbed rats. When inhaled at a concentration of 5 × 10 -2 ppm, santalol caused a significant decrease in total waking time and an increase in total non-rapid eye movement (NREM) sleep time. In order to clarify the mechanism of action, olfactory hypofunction was caused in rats by intranasal application of 5{\%} zinc sulfate solution, and thereafter the effects of inhalation of fragrances were evaluated. In this study, it was found that the impairment of the olfactory system showed no significant effect on the changes in sleep parameters induced by santalol. This result suggests that santalol may act via the circulatory system rather than the olfactory system. That is, santalol is thought to be absorbed into the blood through the respiratory mucosa, and then exert its action. From these results, it is concluded that santalol may be useful in patients having difficulty maintaining sleep without being affected by individual differences in perfume-related preference.",
keywords = "Inhalation, Santalol, Sleep-disturbed rats, Sleep-wake cycle",
author = "Asae Ohmori and Kazuaki Shinomiya and Yoshiaki Utsu and Shin Tokunaga and Yasuyuki Hasegawa and Chiaki Kamei",
year = "2007",
month = "8",
language = "English",
volume = "27",
pages = "167--171",
journal = "Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology",
issn = "1340-2544",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Effect of santalol on the sleep-wake cycle in sleep-disturbed rats

AU - Ohmori, Asae

AU - Shinomiya, Kazuaki

AU - Utsu, Yoshiaki

AU - Tokunaga, Shin

AU - Hasegawa, Yasuyuki

AU - Kamei, Chiaki

PY - 2007/8

Y1 - 2007/8

N2 - Sandalwood oil is widely used in aromatherapy for alleviating various symptoms. Santalol, a major component of sandalwood oil, has been reported to have central nervous system depressant effects such as sedation. In the present study, we investigated the effect of santalol on the sleep-wake cycle in sleep-disturbed rats. When inhaled at a concentration of 5 × 10 -2 ppm, santalol caused a significant decrease in total waking time and an increase in total non-rapid eye movement (NREM) sleep time. In order to clarify the mechanism of action, olfactory hypofunction was caused in rats by intranasal application of 5% zinc sulfate solution, and thereafter the effects of inhalation of fragrances were evaluated. In this study, it was found that the impairment of the olfactory system showed no significant effect on the changes in sleep parameters induced by santalol. This result suggests that santalol may act via the circulatory system rather than the olfactory system. That is, santalol is thought to be absorbed into the blood through the respiratory mucosa, and then exert its action. From these results, it is concluded that santalol may be useful in patients having difficulty maintaining sleep without being affected by individual differences in perfume-related preference.

AB - Sandalwood oil is widely used in aromatherapy for alleviating various symptoms. Santalol, a major component of sandalwood oil, has been reported to have central nervous system depressant effects such as sedation. In the present study, we investigated the effect of santalol on the sleep-wake cycle in sleep-disturbed rats. When inhaled at a concentration of 5 × 10 -2 ppm, santalol caused a significant decrease in total waking time and an increase in total non-rapid eye movement (NREM) sleep time. In order to clarify the mechanism of action, olfactory hypofunction was caused in rats by intranasal application of 5% zinc sulfate solution, and thereafter the effects of inhalation of fragrances were evaluated. In this study, it was found that the impairment of the olfactory system showed no significant effect on the changes in sleep parameters induced by santalol. This result suggests that santalol may act via the circulatory system rather than the olfactory system. That is, santalol is thought to be absorbed into the blood through the respiratory mucosa, and then exert its action. From these results, it is concluded that santalol may be useful in patients having difficulty maintaining sleep without being affected by individual differences in perfume-related preference.

KW - Inhalation

KW - Santalol

KW - Sleep-disturbed rats

KW - Sleep-wake cycle

UR - http://www.scopus.com/inward/record.url?scp=34548857612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548857612&partnerID=8YFLogxK

M3 - Article

C2 - 17879595

AN - SCOPUS:34548857612

VL - 27

SP - 167

EP - 171

JO - Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology

JF - Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology

SN - 1340-2544

IS - 4

ER -