Abstract
We examined the effect of roxithromycin against biofilms formed by Staphylococcus aureus. No combined effect of roxithromycin and imipenem was observed in a biofilm model on coverslips. In a murine model for biofilm formation, however, the combination treatment significantly decreased the number of viable bacterial cells compared with the control. Histologically, neutrophils invaded the bacterial clusters in the roxithromycin treated groups. These findings suggest that roxithromycin can induce the invasion of neutrophils and enhance therapeutic efficacy of imipenem. Confocal laser microscopic observation on glycocalyx production by S. aureus revealed that sub-MIC roxithromycin inhibited glycocalyx production. The effects of roxithromycin on biofilm formation by S. aureus were the eradication of biofilm and the inhibition of biofilm formation. The results of this study indicate that roxithromycin are a potentially effective treatment for S. aureus biofilm associated skin infection.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Skin Research |
| Volume | 1 |
| Issue number | SUPPL. 1 |
| Publication status | Published - Aug 2002 |
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Keywords
- Biofilm
- Imipenem
- Macrolide
- Roxithromycin
- Staphylococcus aureus
ASJC Scopus subject areas
- Dermatology
Cite this
Effect of roxithromycin against biofilm formed by Staphylococcus aureus. / Yamasaki, Osamu; Akiyama, Hisanori; Oono, Takashi; Iwatsuki, Keiji; Arata, Jirô.
In: Skin Research, Vol. 1, No. SUPPL. 1, 08.2002, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of roxithromycin against biofilm formed by Staphylococcus aureus
AU - Yamasaki, Osamu
AU - Akiyama, Hisanori
AU - Oono, Takashi
AU - Iwatsuki, Keiji
AU - Arata, Jirô
PY - 2002/8
Y1 - 2002/8
N2 - We examined the effect of roxithromycin against biofilms formed by Staphylococcus aureus. No combined effect of roxithromycin and imipenem was observed in a biofilm model on coverslips. In a murine model for biofilm formation, however, the combination treatment significantly decreased the number of viable bacterial cells compared with the control. Histologically, neutrophils invaded the bacterial clusters in the roxithromycin treated groups. These findings suggest that roxithromycin can induce the invasion of neutrophils and enhance therapeutic efficacy of imipenem. Confocal laser microscopic observation on glycocalyx production by S. aureus revealed that sub-MIC roxithromycin inhibited glycocalyx production. The effects of roxithromycin on biofilm formation by S. aureus were the eradication of biofilm and the inhibition of biofilm formation. The results of this study indicate that roxithromycin are a potentially effective treatment for S. aureus biofilm associated skin infection.
AB - We examined the effect of roxithromycin against biofilms formed by Staphylococcus aureus. No combined effect of roxithromycin and imipenem was observed in a biofilm model on coverslips. In a murine model for biofilm formation, however, the combination treatment significantly decreased the number of viable bacterial cells compared with the control. Histologically, neutrophils invaded the bacterial clusters in the roxithromycin treated groups. These findings suggest that roxithromycin can induce the invasion of neutrophils and enhance therapeutic efficacy of imipenem. Confocal laser microscopic observation on glycocalyx production by S. aureus revealed that sub-MIC roxithromycin inhibited glycocalyx production. The effects of roxithromycin on biofilm formation by S. aureus were the eradication of biofilm and the inhibition of biofilm formation. The results of this study indicate that roxithromycin are a potentially effective treatment for S. aureus biofilm associated skin infection.
KW - Biofilm
KW - Imipenem
KW - Macrolide
KW - Roxithromycin
KW - Staphylococcus aureus
UR - http://www.scopus.com/inward/record.url?scp=0036705540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036705540&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0036705540
VL - 1
SP - 1
EP - 7
JO - Skin Research
JF - Skin Research
SN - 0018-1390
IS - SUPPL. 1
ER -