Abstract
The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.
| Original language | English |
|---|---|
| Pages (from-to) | 101-109 |
| Number of pages | 9 |
| Journal | Archives of Virology |
| Volume | 99 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Mar 1988 |
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ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Genetics
Cite this
Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice. / Yamada, Masao; Arao, Yujiro; Hatano, A.; Uno, F.; Nii, S.
In: Archives of Virology, Vol. 99, No. 1-2, 03.1988, p. 101-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice
AU - Yamada, Masao
AU - Arao, Yujiro
AU - Hatano, A.
AU - Uno, F.
AU - Nii, S.
PY - 1988/3
Y1 - 1988/3
N2 - The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.
AB - The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023932795&partnerID=8YFLogxK
U2 - 10.1007/BF01311027
DO - 10.1007/BF01311027
M3 - Article
C2 - 3355371
AN - SCOPUS:0023932795
VL - 99
SP - 101
EP - 109
JO - Archives of Virology
JF - Archives of Virology
SN - 0304-8608
IS - 1-2
ER -