Abstract
The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.
Original language | English |
---|---|
Pages (from-to) | 101-109 |
Number of pages | 9 |
Journal | Archives of Virology |
Volume | 99 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Mar 1988 |
ASJC Scopus subject areas
- Virology