Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice

M. Yamada, Y. Arao, A. Hatano, F. Uno, S. Nii

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalArchives of Virology
Volume99
Issue number1-2
DOIs
Publication statusPublished - Mar 1 1988

ASJC Scopus subject areas

  • Virology

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