Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice

M. Yamada; Y. Arao; A. Hatano; F. Uno; S. Nii

doi:10.1007/BF01311027

Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice

M. Yamada, Y. Arao, A. Hatano, F. Uno, S. Nii

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11 Citations (Scopus)

Abstract

The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.

Original language	English
Pages (from-to)	101-109
Number of pages	9
Journal	Archives of Virology
Volume	99
Issue number	1-2
DOIs	https://doi.org/10.1007/BF01311027
Publication status	Published - Mar 1 1988

ASJC Scopus subject areas

Virology

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title = "Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice",

abstract = "The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.",

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AU - Yamada, M.

AU - Arao, Y.

AU - Hatano, A.

AU - Uno, F.

AU - Nii, S.

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AB - The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.

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