Abstract
The antiviral effect of recombinant mouse interferon-β(rMuIFN-β) on herpes simplex virus type 1 (HSV-1) in experimentally infected mice was examined at several stages of infection as a model for the treatment of human HSV infection. Recombinant MuIFN-β protected mice from lethal intraperitoneal challenge with virulent HSV-1 strains. The in vitro reactivation of HSV from latently infected trigeminal ganglia was also suppressed by treatment with rMuIFN-β. Thus, rMuIFN-β was effective against HSV-1 during acute infection and during in vitro reactivation of latent HSV. However, rMuIFN-β was not effective in preventing the establishment of latent infection, or in eliminating a previously established latent infection.
| Original language | English |
|---|---|
| Pages (from-to) | 101-109 |
| Number of pages | 9 |
| Journal | Archives of Virology |
| Volume | 99 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Mar 1 1988 |
ASJC Scopus subject areas
- Virology
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Cite this
Yamada, M., Arao, Y., Hatano, A., Uno, F., & Nii, S. (1988). Effect of recombinant mouse interferon-β on acute and latent herpes simplex infection in mice. Archives of Virology, 99(1-2), 101-109. https://doi.org/10.1007/BF01311027