Abstract
The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose- dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 1237-1239 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 22 |
| Issue number | 11 |
| Publication status | Published - Nov 1999 |
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Keywords
- D-galactosamine
- Hepatic injury
- Hepatoprotective effect
- Propolis extract
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Effect of propolis extract on D-galactosamine-induced hepatic injury in rats. / Sugimoto, Yukio; Tarumi, Tadatsugu; Kaneko, Yoshio; Isayama, Shinji; Kawai, Nobuyuki; Sugimoto, Hiroyuki; Yamada, Hideo; Kamei, Chiaki.
In: Biological and Pharmaceutical Bulletin, Vol. 22, No. 11, 11.1999, p. 1237-1239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of propolis extract on D-galactosamine-induced hepatic injury in rats
AU - Sugimoto, Yukio
AU - Tarumi, Tadatsugu
AU - Kaneko, Yoshio
AU - Isayama, Shinji
AU - Kawai, Nobuyuki
AU - Sugimoto, Hiroyuki
AU - Yamada, Hideo
AU - Kamei, Chiaki
PY - 1999/11
Y1 - 1999/11
N2 - The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose- dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.
AB - The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose- dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.
KW - D-galactosamine
KW - Hepatic injury
KW - Hepatoprotective effect
KW - Propolis extract
UR - http://www.scopus.com/inward/record.url?scp=0033405411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033405411&partnerID=8YFLogxK
M3 - Article
C2 - 10598035
AN - SCOPUS:0033405411
VL - 22
SP - 1237
EP - 1239
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 11
ER -