Effect of propolis extract on D-galactosamine-induced hepatic injury in rats

Yukio Sugimoto, Tadatsugu Tarumi, Yoshio Kaneko, Shinji Isayama, Nobuyuki Kawai, Hiroyuki Sugimoto, Hideo Yamada, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose- dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.

Original languageEnglish
Pages (from-to)1237-1239
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Issue number11
Publication statusPublished - Nov 1999


  • D-galactosamine
  • Hepatic injury
  • Hepatoprotective effect
  • Propolis extract

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


Dive into the research topics of 'Effect of propolis extract on D-galactosamine-induced hepatic injury in rats'. Together they form a unique fingerprint.

Cite this