Effect of propolis extract on D-galactosamine-induced hepatic injury in rats

Yukio Sugimoto, Tadatsugu Tarumi, Yoshio Kaneko, Shinji Isayama, Nobuyuki Kawai, Hiroyuki Sugimoto, Hideo Yamada, Chiaki Kamei

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose- dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.

Original languageEnglish
Pages (from-to)1237-1239
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number11
Publication statusPublished - Nov 1999

Fingerprint

Propolis
Galactosamine
Aspartate Aminotransferases
Alanine Transaminase
Liver
Wounds and Injuries
Serum
Dextrans
Intraperitoneal Injections
Injections

Keywords

  • D-galactosamine
  • Hepatic injury
  • Hepatoprotective effect
  • Propolis extract

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sugimoto, Y., Tarumi, T., Kaneko, Y., Isayama, S., Kawai, N., Sugimoto, H., ... Kamei, C. (1999). Effect of propolis extract on D-galactosamine-induced hepatic injury in rats. Biological and Pharmaceutical Bulletin, 22(11), 1237-1239.

Effect of propolis extract on D-galactosamine-induced hepatic injury in rats. / Sugimoto, Yukio; Tarumi, Tadatsugu; Kaneko, Yoshio; Isayama, Shinji; Kawai, Nobuyuki; Sugimoto, Hiroyuki; Yamada, Hideo; Kamei, Chiaki.

In: Biological and Pharmaceutical Bulletin, Vol. 22, No. 11, 11.1999, p. 1237-1239.

Research output: Contribution to journalArticle

Sugimoto, Y, Tarumi, T, Kaneko, Y, Isayama, S, Kawai, N, Sugimoto, H, Yamada, H & Kamei, C 1999, 'Effect of propolis extract on D-galactosamine-induced hepatic injury in rats', Biological and Pharmaceutical Bulletin, vol. 22, no. 11, pp. 1237-1239.
Sugimoto Y, Tarumi T, Kaneko Y, Isayama S, Kawai N, Sugimoto H et al. Effect of propolis extract on D-galactosamine-induced hepatic injury in rats. Biological and Pharmaceutical Bulletin. 1999 Nov;22(11):1237-1239.
Sugimoto, Yukio ; Tarumi, Tadatsugu ; Kaneko, Yoshio ; Isayama, Shinji ; Kawai, Nobuyuki ; Sugimoto, Hiroyuki ; Yamada, Hideo ; Kamei, Chiaki. / Effect of propolis extract on D-galactosamine-induced hepatic injury in rats. In: Biological and Pharmaceutical Bulletin. 1999 ; Vol. 22, No. 11. pp. 1237-1239.
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