Effect of prophylactic anti-emetics on opioid-induced nausea and vomiting: A retrospective observational cohort study

Tomoki Tamura, Keita Kawakado, Go Makimoto, Masamoto Nakanishi, Shoichi Kuyama

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The guidelines on pharmacotherapy for cancer-related pain advocate active measures against the adverse effects of opioids to increase adherence to medication. However, preventative therapy for the management of nausea and vomiting has not been specified. This study aimed to verify the effects of prophylactic antiemetics in preventing opioid-induced nausea and vomiting. Patients and Methods: We conducted a retrospective analysis of cases at our hospital in which oral opioids or patches were initiated for the management of pain due to malignant tumours from January 2017 to September 2019. Results: Strong opioids were initiated for 349 patients; of these, data for 298 patients were analysed. A total of 193 patients were on anti-emetic prophylaxis. We found that the group that did not receive anti-emetic prophylaxis was significantly more likely to be prescribed an additional antiemetic. Conclusion: Prophylactic administration of antiemetics at the time of initiating opioid analgesics may reduce gastrointestinal toxicity.

Original languageEnglish
Pages (from-to)1737-1742
Number of pages6
JournalIn Vivo
Volume35
Issue number3
DOIs
Publication statusPublished - May 2021
Externally publishedYes

Keywords

  • Anti-emetics
  • Emesis
  • Nausea
  • Opioids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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