Abstract
The present study was undertaken to investigate the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on marble-burying behavior in mice in comparison with those of fluvoxamine and clomipramine. Marble-burying test is extensively used as an animal model for obsessive/compulsive disorder. A significant inhibition in marble-burying behavior was observed with paroxetine, at a dose of 10 mg/kg. The earlier SSRI, fluvoxamine, also significantly inhibited marble-burying behavior at a dose of 30 mg/kg. Although clomipramine, a tricyclic antidepressant, caused an inhibition in marble-burying behavior, a high dose of 100 mg/kg was needed to show a significant effect. On the other hand, all the drugs used in the present study showed no significant changes in spontaneous locomotor activity at doses inhibiting marble-burying behavior. In conclusion, it was confirmed that paroxetine has a potent inhibitory effect on marble-burying behavior in mice, and could have a similar antiobsessive/ anticompulsive activity in human beings.
| Original language | English |
|---|---|
| Pages (from-to) | 685-687 |
| Number of pages | 3 |
| Journal | Methods and Findings in Experimental and Clinical Pharmacology |
| Volume | 27 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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Keywords
- Clomipramine
- Fluvoxamine
- Marble-burying behavior
- Mice
- Paroxetine
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Effect of paroxetine on marble-burying behavior in mice. / Shinomiya, K.; Fujii, Y.; Sugimoto, Yukio; Azuma, N.; Tokunaga, S.; Kitazumi, K.; Kamei, C.
In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 27, No. 10, 12.2005, p. 685-687.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of paroxetine on marble-burying behavior in mice
AU - Shinomiya, K.
AU - Fujii, Y.
AU - Sugimoto, Yukio
AU - Azuma, N.
AU - Tokunaga, S.
AU - Kitazumi, K.
AU - Kamei, C.
PY - 2005/12
Y1 - 2005/12
N2 - The present study was undertaken to investigate the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on marble-burying behavior in mice in comparison with those of fluvoxamine and clomipramine. Marble-burying test is extensively used as an animal model for obsessive/compulsive disorder. A significant inhibition in marble-burying behavior was observed with paroxetine, at a dose of 10 mg/kg. The earlier SSRI, fluvoxamine, also significantly inhibited marble-burying behavior at a dose of 30 mg/kg. Although clomipramine, a tricyclic antidepressant, caused an inhibition in marble-burying behavior, a high dose of 100 mg/kg was needed to show a significant effect. On the other hand, all the drugs used in the present study showed no significant changes in spontaneous locomotor activity at doses inhibiting marble-burying behavior. In conclusion, it was confirmed that paroxetine has a potent inhibitory effect on marble-burying behavior in mice, and could have a similar antiobsessive/ anticompulsive activity in human beings.
AB - The present study was undertaken to investigate the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI), on marble-burying behavior in mice in comparison with those of fluvoxamine and clomipramine. Marble-burying test is extensively used as an animal model for obsessive/compulsive disorder. A significant inhibition in marble-burying behavior was observed with paroxetine, at a dose of 10 mg/kg. The earlier SSRI, fluvoxamine, also significantly inhibited marble-burying behavior at a dose of 30 mg/kg. Although clomipramine, a tricyclic antidepressant, caused an inhibition in marble-burying behavior, a high dose of 100 mg/kg was needed to show a significant effect. On the other hand, all the drugs used in the present study showed no significant changes in spontaneous locomotor activity at doses inhibiting marble-burying behavior. In conclusion, it was confirmed that paroxetine has a potent inhibitory effect on marble-burying behavior in mice, and could have a similar antiobsessive/ anticompulsive activity in human beings.
KW - Clomipramine
KW - Fluvoxamine
KW - Marble-burying behavior
KW - Mice
KW - Paroxetine
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UR - http://www.scopus.com/inward/citedby.url?scp=33144477029&partnerID=8YFLogxK
U2 - 10.1358/mf.2005.27.10.948883
DO - 10.1358/mf.2005.27.10.948883
M3 - Article
C2 - 16395417
AN - SCOPUS:33144477029
VL - 27
SP - 685
EP - 687
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology
SN - 0379-0355
IS - 10
ER -