Abstract
This study investigated the effect of oxygen substituents in the benzoyl part of N-(2-iodophenyl)benzamide on the coupling position in its Pd-assisted biaryl coupling reaction. Benzamide with methylenedioxy and acyloxy groups yielded the ortho-product formed predominantly by connection to a more hindered carbon. The mechanism is discussed from the perspectives of both steric and coordinated effects.
Original language | English |
---|---|
Pages (from-to) | 6091-6094 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 36 |
DOIs | |
Publication status | Published - Sep 5 2005 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry