Effect of oral administration of 3,3′,4,4′,5- pentachlorobiphyenl on the intestinal microbiota of Sprague-Dawley rats

Kaoru Yamazaki, Takehito Suzuki, Mitsuyuki Shirai, Tatsuya Takizawa, Tadashi Shinoda, Toshio Masaoka, Fumiaki Akahori, Hidetoshi Morita

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of the endocrine-disrupting chemical 3,3′,4,4′,5- pentachlorobiphyenl (PCB 126) on intestinal microbiota after oral administration, and the improvement of intestinal microbiota and feces quantity by the subsequent administration of Lactobacillus acidophilus or Lactobacillus reuteri was investigated. All the rats were given 100 μg/kg bodyweight of PCB 126. The changes in bacterial counts were confirmed using a culture method. The administration of PCB 126 tended to decrease the bacterial counts of lactobacilli (109.6-1010.2 to 108.8-10 9.2) and bifidobacteria (105.3-106.1 to 10 3.6-104.2), and to increase those of Enterobacteriaceae (108.2-109.1 to 109.4-1010.3) and staphylococci (106.6-107.4 to 107.2-10 8.4) compared to no PCB 126 administration. After administration of PCB 126, L. acidophilus or L. reuteri orally administered to rats caused Enterobacteriaceae and staphylococci counts to decrease, suggesting that the intestinal microbiota was improved by the lactobacilli. The administration of L. acidophilus and L. reuteri improved the balance of intestinal microbiota, and defecation volume returned to its normal level. L. acidophilus and L. reuteri have a remedial effect on intestinal microbiota affected by PCB 126 and can function to lessen accumulated PCB 126 volume.

Original languageEnglish
Pages (from-to)391-400
Number of pages10
JournalAnimal Science Journal
Volume79
Issue number3
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Fingerprint

3,4,5,3',4'-pentachlorobiphenyl
Lactobacillus reuteri
intestinal microorganisms
oral administration
Lactobacillus acidophilus
Oral Administration
Sprague Dawley Rats
rats
Enterobacteriaceae
Staphylococcus
Lactobacillus
plate count
Bacterial Load
endocrine-disrupting chemicals
defecation
Bifidobacterium
Endocrine Disruptors
Defecation
feces
Gastrointestinal Microbiome

Keywords

  • 3,3′,4,4′,5-pentachlorobiphyenl
  • Endocrine-disrupting chemical
  • Intestinal microbiota
  • Lactobacilli

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • veterinary(all)

Cite this

Effect of oral administration of 3,3′,4,4′,5- pentachlorobiphyenl on the intestinal microbiota of Sprague-Dawley rats. / Yamazaki, Kaoru; Suzuki, Takehito; Shirai, Mitsuyuki; Takizawa, Tatsuya; Shinoda, Tadashi; Masaoka, Toshio; Akahori, Fumiaki; Morita, Hidetoshi.

In: Animal Science Journal, Vol. 79, No. 3, 06.2008, p. 391-400.

Research output: Contribution to journalArticle

Yamazaki, Kaoru ; Suzuki, Takehito ; Shirai, Mitsuyuki ; Takizawa, Tatsuya ; Shinoda, Tadashi ; Masaoka, Toshio ; Akahori, Fumiaki ; Morita, Hidetoshi. / Effect of oral administration of 3,3′,4,4′,5- pentachlorobiphyenl on the intestinal microbiota of Sprague-Dawley rats. In: Animal Science Journal. 2008 ; Vol. 79, No. 3. pp. 391-400.
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