Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats

Mikihiko Kogo, Atsuyuki Mori, Hidehiko Koizumi, Koji Ishihama, Seiji Iida, Susumu Tanaka, Tokuzo Matsuya

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

N-methyl-D,L-aspartate acid and bicuculline are required to enhance the trigeminal rhythmic activities in an in vitro isolated brainstem block preparation. In this study, we analyzed the effect of norepinephrine on the trigeminal neural circuit underlying rhythmic jaw movements. Rhythmic trigeminal activity is observed in brainstem preparations (inferior colliculus to obex) only following blockade of α2-adrenoceptors with idazoxan. This observation, combined with the inhibition of rhythm by α2-adrenoceptor agonists suggests endogenous α2-adrenoceptor mediated inhibition of trigeminal networks. A complex noradrenergic modulation of trigeminal systems is further supported by the prazosin-sensitive potentiation of rhythm by bath application of the α1-adrenoceptor agonist phenylephrine. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalBrain Research Bulletin
Volume53
Issue number2
DOIs
Publication statusPublished - Sep 15 2000
Externally publishedYes

Fingerprint

Adrenergic Receptors
Brain Stem
Idazoxan
Inferior Colliculi
Bicuculline
Prazosin
Phenylephrine
N-Methylaspartate
Jaw
Baths
Aspartic Acid
Norepinephrine
Acids

Keywords

  • In vitro brainstem preparation
  • Mastication
  • Norepinephrine
  • Rhythm generation
  • Trigeminal motor activity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats. / Kogo, Mikihiko; Mori, Atsuyuki; Koizumi, Hidehiko; Ishihama, Koji; Iida, Seiji; Tanaka, Susumu; Matsuya, Tokuzo.

In: Brain Research Bulletin, Vol. 53, No. 2, 15.09.2000, p. 171-174.

Research output: Contribution to journalArticle

Kogo, M, Mori, A, Koizumi, H, Ishihama, K, Iida, S, Tanaka, S & Matsuya, T 2000, 'Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats', Brain Research Bulletin, vol. 53, no. 2, pp. 171-174. https://doi.org/10.1016/S0361-9230(00)00322-1
Kogo, Mikihiko ; Mori, Atsuyuki ; Koizumi, Hidehiko ; Ishihama, Koji ; Iida, Seiji ; Tanaka, Susumu ; Matsuya, Tokuzo. / Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats. In: Brain Research Bulletin. 2000 ; Vol. 53, No. 2. pp. 171-174.
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