Abstract
Objective: To investigate the effect of non-surgical periodontal therapy on insulin resistance and sensitivity among individuals with borderline diabetes not receiving medications. Methods: A crossover, randomized controlled trial was conducted among participants with borderline diabetes diagnosed by a 75-g oral glucose tolerance test. Participants were randomly assigned to either an early or later intervention group. The early intervention group underwent non-surgical periodontal therapy of scaling and root planing during the first 6 months, followed by a 6-month non-intervention period. The order was reversed in the later intervention group. Primary outcomes included: fasting or post-load serum glucose and insulin, body mass index (BMI), HOMA-IR, HOMA-β, and Matsuda Index. Results: Seventy-four participants were randomized, and 71 participants completed the trial. There were no significant differences between groups in glucose and insulin concentrations during the intervention and non-intervention periods. When analyzed within groups by median-split of bleeding on probing (BOP)levels before intervention, the lower BOP group showed improved changes in BMI, HOMA-IR, HOMA-β, and Matsuda Index (P < 0.05). Further, we observed a positive correlation between baseline BOP and change in BMI (P = 0.06). Change in BMI was positively correlated with changes in HbA 1c , HOMA-IR, and HOMA-β (P < 0.05), and inversely correlated with change in Matsuda Index (P = 0.001). Conclusions: Periodontal therapy had no significant effect on markers related to insulin and glucose metabolism among individuals with borderline diabetes. However, participants with a lower BOP (%)showed significant improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index. Clinical significance: Among individuals diagnosed with borderline diabetes, those who had <37% of a lower BOP (%)showed potential improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index following non-surgical periodontal therapy.
| Original language | English |
|---|---|
| Journal | Journal of Dentistry |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Borderline diabetes
- Insulin resistance and sensitivity
- Non-surgical periodontal therapy
- Periodontitis
- Randomized controlled trial
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Effect of non-surgical periodontal therapy on insulin resistance and insulin sensitivity among individuals with borderline diabetes : A randomized controlled trial. / Nishioka, Shinji; Maruyama, Koutatsu; Tanigawa, Takeshi; Miyoshi, Noriko; Eguchi, Eri; Nishida, Wataru; Osawa, Haruhiko; Saito, Isao.
In: Journal of Dentistry, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of non-surgical periodontal therapy on insulin resistance and insulin sensitivity among individuals with borderline diabetes
T2 - A randomized controlled trial
AU - Nishioka, Shinji
AU - Maruyama, Koutatsu
AU - Tanigawa, Takeshi
AU - Miyoshi, Noriko
AU - Eguchi, Eri
AU - Nishida, Wataru
AU - Osawa, Haruhiko
AU - Saito, Isao
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective: To investigate the effect of non-surgical periodontal therapy on insulin resistance and sensitivity among individuals with borderline diabetes not receiving medications. Methods: A crossover, randomized controlled trial was conducted among participants with borderline diabetes diagnosed by a 75-g oral glucose tolerance test. Participants were randomly assigned to either an early or later intervention group. The early intervention group underwent non-surgical periodontal therapy of scaling and root planing during the first 6 months, followed by a 6-month non-intervention period. The order was reversed in the later intervention group. Primary outcomes included: fasting or post-load serum glucose and insulin, body mass index (BMI), HOMA-IR, HOMA-β, and Matsuda Index. Results: Seventy-four participants were randomized, and 71 participants completed the trial. There were no significant differences between groups in glucose and insulin concentrations during the intervention and non-intervention periods. When analyzed within groups by median-split of bleeding on probing (BOP)levels before intervention, the lower BOP group showed improved changes in BMI, HOMA-IR, HOMA-β, and Matsuda Index (P < 0.05). Further, we observed a positive correlation between baseline BOP and change in BMI (P = 0.06). Change in BMI was positively correlated with changes in HbA 1c , HOMA-IR, and HOMA-β (P < 0.05), and inversely correlated with change in Matsuda Index (P = 0.001). Conclusions: Periodontal therapy had no significant effect on markers related to insulin and glucose metabolism among individuals with borderline diabetes. However, participants with a lower BOP (%)showed significant improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index. Clinical significance: Among individuals diagnosed with borderline diabetes, those who had <37% of a lower BOP (%)showed potential improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index following non-surgical periodontal therapy.
AB - Objective: To investigate the effect of non-surgical periodontal therapy on insulin resistance and sensitivity among individuals with borderline diabetes not receiving medications. Methods: A crossover, randomized controlled trial was conducted among participants with borderline diabetes diagnosed by a 75-g oral glucose tolerance test. Participants were randomly assigned to either an early or later intervention group. The early intervention group underwent non-surgical periodontal therapy of scaling and root planing during the first 6 months, followed by a 6-month non-intervention period. The order was reversed in the later intervention group. Primary outcomes included: fasting or post-load serum glucose and insulin, body mass index (BMI), HOMA-IR, HOMA-β, and Matsuda Index. Results: Seventy-four participants were randomized, and 71 participants completed the trial. There were no significant differences between groups in glucose and insulin concentrations during the intervention and non-intervention periods. When analyzed within groups by median-split of bleeding on probing (BOP)levels before intervention, the lower BOP group showed improved changes in BMI, HOMA-IR, HOMA-β, and Matsuda Index (P < 0.05). Further, we observed a positive correlation between baseline BOP and change in BMI (P = 0.06). Change in BMI was positively correlated with changes in HbA 1c , HOMA-IR, and HOMA-β (P < 0.05), and inversely correlated with change in Matsuda Index (P = 0.001). Conclusions: Periodontal therapy had no significant effect on markers related to insulin and glucose metabolism among individuals with borderline diabetes. However, participants with a lower BOP (%)showed significant improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index. Clinical significance: Among individuals diagnosed with borderline diabetes, those who had <37% of a lower BOP (%)showed potential improvements in BMI, fasting serum insulin, HOMA-IR, HOMA-β and Matsuda Index following non-surgical periodontal therapy.
KW - Borderline diabetes
KW - Insulin resistance and sensitivity
KW - Non-surgical periodontal therapy
KW - Periodontitis
KW - Randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=85065176092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065176092&partnerID=8YFLogxK
U2 - 10.1016/j.jdent.2019.04.005
DO - 10.1016/j.jdent.2019.04.005
M3 - Article
JO - Journal of Dentistry
JF - Journal of Dentistry
SN - 0300-5712
ER -