Abstract
Aim: For donation after cardiac death (DCD) transplantation to achieve its full potential, multiorgan retrieval is desirable. Although there are several novel individual techniques recently described for DCD lung donation, they have not been evaluated or compared in a DCD multiorgan scenario. Description: This study describes (i) the technical aspects and (ii) early lung and abdominal organ performance of several combinations of DCD donor liver, kidney and lung retrieval techniques that would mimic common DCD clinical scenarios. Evaluation: Lung oxygenation, urine production, bile production and biochemical measures were assessed as the outcome of a complex ex vivo lung, liver and kidney perfusion DCD model. Conclusion: Successful ex vivo multiorgan perfusion was possible following the three retrieval techniques tested, with excellent oxygenation over a 2-h assessment period, identical to prior studies where the lungs were tested alone. Multiorgan DCD retrieval, including lungs of good quality, is possible from a variety of clinical scenarios and should therefore be considered with all DCD retrieval opportunities.
| Original language | English |
|---|---|
| Pages (from-to) | 262-265 |
| Number of pages | 4 |
| Journal | ANZ Journal of Surgery |
| Volume | 78 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2008 |
| Externally published | Yes |
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Keywords
- Kidney
- Lung
- Organ donation
- Transplantation
ASJC Scopus subject areas
- Surgery
Cite this
Effect of multiorgan donation after cardiac death retrieval on lung performance. / Snell, Gregory I.; Levvey, Bronwyn; Oto, Takahiro; McEgan, Robin; Mennan, Mark; Eriksson, Leif; Williams, Trevor; Rosenfeldt, Franklin.
In: ANZ Journal of Surgery, Vol. 78, No. 4, 04.2008, p. 262-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of multiorgan donation after cardiac death retrieval on lung performance
AU - Snell, Gregory I.
AU - Levvey, Bronwyn
AU - Oto, Takahiro
AU - McEgan, Robin
AU - Mennan, Mark
AU - Eriksson, Leif
AU - Williams, Trevor
AU - Rosenfeldt, Franklin
PY - 2008/4
Y1 - 2008/4
N2 - Aim: For donation after cardiac death (DCD) transplantation to achieve its full potential, multiorgan retrieval is desirable. Although there are several novel individual techniques recently described for DCD lung donation, they have not been evaluated or compared in a DCD multiorgan scenario. Description: This study describes (i) the technical aspects and (ii) early lung and abdominal organ performance of several combinations of DCD donor liver, kidney and lung retrieval techniques that would mimic common DCD clinical scenarios. Evaluation: Lung oxygenation, urine production, bile production and biochemical measures were assessed as the outcome of a complex ex vivo lung, liver and kidney perfusion DCD model. Conclusion: Successful ex vivo multiorgan perfusion was possible following the three retrieval techniques tested, with excellent oxygenation over a 2-h assessment period, identical to prior studies where the lungs were tested alone. Multiorgan DCD retrieval, including lungs of good quality, is possible from a variety of clinical scenarios and should therefore be considered with all DCD retrieval opportunities.
AB - Aim: For donation after cardiac death (DCD) transplantation to achieve its full potential, multiorgan retrieval is desirable. Although there are several novel individual techniques recently described for DCD lung donation, they have not been evaluated or compared in a DCD multiorgan scenario. Description: This study describes (i) the technical aspects and (ii) early lung and abdominal organ performance of several combinations of DCD donor liver, kidney and lung retrieval techniques that would mimic common DCD clinical scenarios. Evaluation: Lung oxygenation, urine production, bile production and biochemical measures were assessed as the outcome of a complex ex vivo lung, liver and kidney perfusion DCD model. Conclusion: Successful ex vivo multiorgan perfusion was possible following the three retrieval techniques tested, with excellent oxygenation over a 2-h assessment period, identical to prior studies where the lungs were tested alone. Multiorgan DCD retrieval, including lungs of good quality, is possible from a variety of clinical scenarios and should therefore be considered with all DCD retrieval opportunities.
KW - Kidney
KW - Lung
KW - Organ donation
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=41149123219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41149123219&partnerID=8YFLogxK
U2 - 10.1111/j.1445-2197.2008.04432.x
DO - 10.1111/j.1445-2197.2008.04432.x
M3 - Article
VL - 78
SP - 262
EP - 265
JO - ANZ Journal of Surgery
JF - ANZ Journal of Surgery
SN - 1445-1433
IS - 4
ER -