Effect of mometasone furoate by topical application on allergic rhinitis model in rats

Yukio Sugimoto, Keisuke Ishizawa, Kouichi Saitou, Genzo Suzuki, Tadatsugu Tarumi, Hiroto Nakahara, Yasushi Kirino, Chiaki Kamei

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14 Citations (Scopus)

Abstract

The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate. Topical application of both drugs inhibited dose-dependently the increase of nasal symptoms (sneezing and nasal rubbing) after antigen challenge to the nasal cavity of actively sensitized rats. Mometasone furoate and fluticasone propionate at concentrations of 0.01 or 0.1% significantly inhibited both nasal rubbing and sneezing 1 h after topical application of both drugs. The relative potencies of mometasone furoate in nasal rubbing and sneezing compared to fluticasone propionate were 5.01 and 6.87, respectively. Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibited the increase of antigen-induced nasal rubbing even 6 h after topical application, indicating that both drugs have a long-lasting effect. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalPharmacology
Volume61
Issue number2
Publication statusPublished - Aug 2000

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Keywords

  • Allergic rhinitis
  • Fluticasone propionate
  • Mometasone furoate
  • Nasal rubbing
  • Sneezing

ASJC Scopus subject areas

  • Pharmacology

Cite this

Sugimoto, Y., Ishizawa, K., Saitou, K., Suzuki, G., Tarumi, T., Nakahara, H., Kirino, Y., & Kamei, C. (2000). Effect of mometasone furoate by topical application on allergic rhinitis model in rats. Pharmacology, 61(2), 91-95.