Effect of molecular sieves in the liquid-phase synthesis of nucleotides via the phosphoramidite method

Yoshihiro Hayakawa, Akiyoshi Hirata, Jun Ichiro Sugimoto, Rie Kawai, Akira Sakakura, Masanori Kataoka

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

It is demonstrated that the reaction of a nucleoside phosphoramidite and a nucleoside aided by a suitable promoter in the presence of molecular sieves 3A or 4A in a liquid phase is efficiently performed by the use of stoichiometric amounts of the reactants to give the desired coupling product in an excellent yield.

Original languageEnglish
Pages (from-to)8823-8826
Number of pages4
JournalTetrahedron
Volume57
Issue number42
DOIs
Publication statusPublished - Oct 15 2001
Externally publishedYes

Fingerprint

Molecular sieves
Nucleosides
Nucleotides
Liquids
phosphoramidite

Keywords

  • Molecular sieves
  • Nucleotides
  • Phosphoramidites

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Effect of molecular sieves in the liquid-phase synthesis of nucleotides via the phosphoramidite method. / Hayakawa, Yoshihiro; Hirata, Akiyoshi; Sugimoto, Jun Ichiro; Kawai, Rie; Sakakura, Akira; Kataoka, Masanori.

In: Tetrahedron, Vol. 57, No. 42, 15.10.2001, p. 8823-8826.

Research output: Contribution to journalArticle

Hayakawa, Yoshihiro ; Hirata, Akiyoshi ; Sugimoto, Jun Ichiro ; Kawai, Rie ; Sakakura, Akira ; Kataoka, Masanori. / Effect of molecular sieves in the liquid-phase synthesis of nucleotides via the phosphoramidite method. In: Tetrahedron. 2001 ; Vol. 57, No. 42. pp. 8823-8826.
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