Effect of molecular sieves in the liquid-phase synthesis of nucleotides via the phosphoramidite method

Yoshihiro Hayakawa, Akiyoshi Hirata, Jun Ichiro Sugimoto, Rie Kawai, Akira Sakakura, Masanori Kataoka

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

It is demonstrated that the reaction of a nucleoside phosphoramidite and a nucleoside aided by a suitable promoter in the presence of molecular sieves 3A or 4A in a liquid phase is efficiently performed by the use of stoichiometric amounts of the reactants to give the desired coupling product in an excellent yield.

Original languageEnglish
Pages (from-to)8823-8826
Number of pages4
JournalTetrahedron
Volume57
Issue number42
DOIs
Publication statusPublished - Oct 15 2001
Externally publishedYes

Keywords

  • Molecular sieves
  • Nucleotides
  • Phosphoramidites

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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