Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia

H. Ichikawa, S. C. Lin, S. Y. Tsai, M. J. Tsai, T. Sugimoto

Research output: Contribution to journalArticle

Abstract

Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glossopharyngeal and vagal ganglia contained abundant CGRP-, tyrosine hydroxylase- and calbindin D-28k-immunoreactive (IR) neurons. In the ganglia of mCOUP-TFI knockout mice, a 38% decrease of CGRP-IR neurons was detected. However, the number of tyrosine hydroxylase- or calbindin D-28k-neurons was not altered by the mCOUP-TFI deficiency. In the tongue of knockout mice, the number of CGRP-IR nerve fibers decreased compared to wild-type and heterozygous mice. The development of CGRP-IR petrosal neurons, which supply innervation of the tongue, may depend on mCOUP-TFI.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalBrain Research
Volume1014
Issue number1-2
DOIs
Publication statusPublished - Jul 16 2004

Fingerprint

Sensory Ganglia
Calcitonin Gene-Related Peptide
Calbindins
Tyrosine 3-Monooxygenase
Knockout Mice
Ganglia
Neurons
Tongue
Sensory Receptor Cells
Nerve Fibers
Immunohistochemistry

Keywords

  • Calbindin D-28k
  • Calcitonin gene-related peptide
  • Knockout mouse
  • mCOUP-TF
  • Petrosal neuron
  • Sensory systems
  • Somatic and visceral afferents
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ichikawa, H., Lin, S. C., Tsai, S. Y., Tsai, M. J., & Sugimoto, T. (2004). Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia. Brain Research, 1014(1-2), 247-250. https://doi.org/10.1016/j.brainres.2004.04.024

Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia. / Ichikawa, H.; Lin, S. C.; Tsai, S. Y.; Tsai, M. J.; Sugimoto, T.

In: Brain Research, Vol. 1014, No. 1-2, 16.07.2004, p. 247-250.

Research output: Contribution to journalArticle

Ichikawa, H, Lin, SC, Tsai, SY, Tsai, MJ & Sugimoto, T 2004, 'Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia', Brain Research, vol. 1014, no. 1-2, pp. 247-250. https://doi.org/10.1016/j.brainres.2004.04.024
Ichikawa, H. ; Lin, S. C. ; Tsai, S. Y. ; Tsai, M. J. ; Sugimoto, T. / Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia. In: Brain Research. 2004 ; Vol. 1014, No. 1-2. pp. 247-250.
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