Abstract
Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glossopharyngeal and vagal ganglia contained abundant CGRP-, tyrosine hydroxylase- and calbindin D-28k-immunoreactive (IR) neurons. In the ganglia of mCOUP-TFI knockout mice, a 38% decrease of CGRP-IR neurons was detected. However, the number of tyrosine hydroxylase- or calbindin D-28k-neurons was not altered by the mCOUP-TFI deficiency. In the tongue of knockout mice, the number of CGRP-IR nerve fibers decreased compared to wild-type and heterozygous mice. The development of CGRP-IR petrosal neurons, which supply innervation of the tongue, may depend on mCOUP-TFI.
| Original language | English |
|---|---|
| Pages (from-to) | 247-250 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 1014 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jul 16 2004 |
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Keywords
- Calbindin D-28k
- Calcitonin gene-related peptide
- Knockout mouse
- mCOUP-TF
- Petrosal neuron
- Sensory systems
- Somatic and visceral afferents
- Tyrosine hydroxylase
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia. / Ichikawa, H.; Lin, S. C.; Tsai, S. Y.; Tsai, M. J.; Sugimoto, T.
In: Brain Research, Vol. 1014, No. 1-2, 16.07.2004, p. 247-250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia
AU - Ichikawa, H.
AU - Lin, S. C.
AU - Tsai, S. Y.
AU - Tsai, M. J.
AU - Sugimoto, T.
PY - 2004/7/16
Y1 - 2004/7/16
N2 - Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glossopharyngeal and vagal ganglia contained abundant CGRP-, tyrosine hydroxylase- and calbindin D-28k-immunoreactive (IR) neurons. In the ganglia of mCOUP-TFI knockout mice, a 38% decrease of CGRP-IR neurons was detected. However, the number of tyrosine hydroxylase- or calbindin D-28k-neurons was not altered by the mCOUP-TFI deficiency. In the tongue of knockout mice, the number of CGRP-IR nerve fibers decreased compared to wild-type and heterozygous mice. The development of CGRP-IR petrosal neurons, which supply innervation of the tongue, may depend on mCOUP-TFI.
AB - Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glossopharyngeal and vagal ganglia contained abundant CGRP-, tyrosine hydroxylase- and calbindin D-28k-immunoreactive (IR) neurons. In the ganglia of mCOUP-TFI knockout mice, a 38% decrease of CGRP-IR neurons was detected. However, the number of tyrosine hydroxylase- or calbindin D-28k-neurons was not altered by the mCOUP-TFI deficiency. In the tongue of knockout mice, the number of CGRP-IR nerve fibers decreased compared to wild-type and heterozygous mice. The development of CGRP-IR petrosal neurons, which supply innervation of the tongue, may depend on mCOUP-TFI.
KW - Calbindin D-28k
KW - Calcitonin gene-related peptide
KW - Knockout mouse
KW - mCOUP-TF
KW - Petrosal neuron
KW - Sensory systems
KW - Somatic and visceral afferents
KW - Tyrosine hydroxylase
UR - http://www.scopus.com/inward/record.url?scp=2942705681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942705681&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2004.04.024
DO - 10.1016/j.brainres.2004.04.024
M3 - Article
C2 - 15213010
AN - SCOPUS:2942705681
VL - 1014
SP - 247
EP - 250
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -