Effect of low-dose vasopressin infusion on vital organ blood flow in the conscious normal septic sheep

D. Di Giantomasso, Hiroshi Morimatsu, Rinaldo Bellomo, C. N. May

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The effect of low-dose vasopressin (AVP) on vital regional circulations may be clinically relevant but has not been fully described. We sought to determine the effect of low-dose AVP on systemic haemodynamics, coronary, mesenteric and renal circulations in the conscious normal and septic mammal. We studied seven Merino sheep using a prospective randomized cross-over double-blind placebo-controlled animal design. We inserted flow probes around aorta, coronary, mesenteric and renal arteries and, three weeks later, we infused low-dose AVP (0.02 IU/min) or placebo in the normal and septic state induced by intravenous E.coli. In normal sheep, AVP (0.02 IU/min) induced a 17% decrease in mesenteric blood flow (393.0±134.9 vs 472.1±163.8 ml/min, P

Original languageEnglish
Pages (from-to)427-433
Number of pages7
JournalAnaesthesia and Intensive Care
Volume34
Issue number4
Publication statusPublished - Aug 2006
Externally publishedYes

Fingerprint

Vasopressins
Sheep
Placebos
Splanchnic Circulation
Coronary Circulation
Mesenteric Arteries
Renal Circulation
Renal Artery
Aorta
Mammals
Coronary Vessels
Hemodynamics
Escherichia coli

Keywords

  • Coronary blood flow
  • Creatinine clearance
  • Mesenteric blood flow
  • Renal blood flow
  • Sepsis
  • Septic shock
  • Vasopressin

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Effect of low-dose vasopressin infusion on vital organ blood flow in the conscious normal septic sheep. / Di Giantomasso, D.; Morimatsu, Hiroshi; Bellomo, Rinaldo; May, C. N.

In: Anaesthesia and Intensive Care, Vol. 34, No. 4, 08.2006, p. 427-433.

Research output: Contribution to journalArticle

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