Effect of Low Dose Cyclophosphamide on the Synthesis of Acute Phase Protein and Its Significance for Cancer Chemotherapy

Hiromi Iwagaki, Akio Hizuta, Toshiyoshi Fujiwara, Jose Antonio Perdomo, Noriaki Tanaka, Kunzo Orita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Patients with far advanced colorectal cancers received chemotherapy consisting of low-dose cyclophosphamide (LDCY) 333 mg/m2 every four weeks intravenously and by oral administration of 5'-DFUR (a masked compound of 5-Fluorouracil). Serum levels of immunosuppressive acidic protein (IAP), an acute phase protein, were measured every four weeks for a total of thirty-one LDCY trials of ten patients. LDCY chemotherapy significantly decreased the IAP levels in cancer patients with high IAP levels. These results suggested that LDCY chemotherapy could counteract host responses against tumors and could have decreased immunosuppressive responses in cancer patients.

Original languageEnglish
Pages (from-to)271-272
Number of pages2
JournalActa Medica Okayama
Volume50
Issue number5
Publication statusPublished - Oct 1996

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Chemotherapy
Acute-Phase Proteins
Cyclophosphamide
Drug Therapy
Neoplasms
Immunosuppressive Agents
Fluorouracil
Oral Administration
Tumors
Colorectal Neoplasms
Serum
immunosuppressive acidic protein

Keywords

  • Acute phase protein
  • Immunosuppressive acidic protein
  • Low-dose cyclophosphamide

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of Low Dose Cyclophosphamide on the Synthesis of Acute Phase Protein and Its Significance for Cancer Chemotherapy. / Iwagaki, Hiromi; Hizuta, Akio; Fujiwara, Toshiyoshi; Perdomo, Jose Antonio; Tanaka, Noriaki; Orita, Kunzo.

In: Acta Medica Okayama, Vol. 50, No. 5, 10.1996, p. 271-272.

Research output: Contribution to journalArticle

Iwagaki, Hiromi ; Hizuta, Akio ; Fujiwara, Toshiyoshi ; Perdomo, Jose Antonio ; Tanaka, Noriaki ; Orita, Kunzo. / Effect of Low Dose Cyclophosphamide on the Synthesis of Acute Phase Protein and Its Significance for Cancer Chemotherapy. In: Acta Medica Okayama. 1996 ; Vol. 50, No. 5. pp. 271-272.
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