Abstract
Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.
| Original language | English |
|---|---|
| Pages (from-to) | 49-52 |
| Number of pages | 4 |
| Journal | Japanese Pharmacology and Therapeutics |
| Volume | 24 |
| Issue number | 1 |
| Publication status | Published - Feb 21 1996 |
Keywords
- Antiallergic drugs
- Histamine release
- Loratadine
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)