Effect of loratadine on histamine release induced by antigen-antibody reaction

Chiaki Kamei, Yukio Sugimoto, Masako Yamaji, Miho Takada

Research output: Contribution to journalArticlepeer-review


Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalJapanese Pharmacology and Therapeutics
Issue number1
Publication statusPublished - Feb 21 1996


  • Antiallergic drugs
  • Histamine release
  • Loratadine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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