Effect of loratadine on histamine release induced by antigen-antibody reaction

Chiaki Kamei, Yukio Sugimoto, Masako Yamaji, Miho Takada

Research output: Contribution to journalArticle

Abstract

Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalJapanese Pharmacology and Therapeutics
Volume24
Issue number1
Publication statusPublished - 1996

Fingerprint

Loratadine
Antigen-Antibody Reactions
Histamine Release
Mast Cells
Terfenadine
Guinea Pigs
Antigens
Lung

Keywords

  • Antiallergic drugs
  • Histamine release
  • Loratadine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Effect of loratadine on histamine release induced by antigen-antibody reaction. / Kamei, Chiaki; Sugimoto, Yukio; Yamaji, Masako; Takada, Miho.

In: Japanese Pharmacology and Therapeutics, Vol. 24, No. 1, 1996, p. 49-52.

Research output: Contribution to journalArticle

Kamei, Chiaki ; Sugimoto, Yukio ; Yamaji, Masako ; Takada, Miho. / Effect of loratadine on histamine release induced by antigen-antibody reaction. In: Japanese Pharmacology and Therapeutics. 1996 ; Vol. 24, No. 1. pp. 49-52.
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