Effect of loratadine on histamine release induced by antigen-antibody reaction

Chiaki Kamei; Yukio Sugimoto; Masako Yamaji; Miho Takada

Effect of loratadine on histamine release induced by antigen-antibody reaction

Chiaki Kamei, Yukio Sugimoto, Masako Yamaji, Miho Takada

Research output: Contribution to journal › Article › peer-review

Abstract

Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC ₅₀ was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.

Original language	English
Pages (from-to)	49-52
Number of pages	4
Journal	Japanese Pharmacology and Therapeutics
Volume	24
Issue number	1
Publication status	Published - Feb 21 1996

Keywords

Antiallergic drugs
Histamine release
Loratadine

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "Effect of loratadine on histamine release induced by antigen-antibody reaction",

abstract = "Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.",

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AU - Takada, Miho

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N2 - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.

AB - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.

KW - Antiallergic drugs

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