Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.
|Number of pages||4|
|Journal||Japanese Pharmacology and Therapeutics|
|Publication status||Published - Feb 21 1996|
- Antiallergic drugs
- Histamine release
ASJC Scopus subject areas
- Pharmacology (medical)