Abstract
Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.
| Original language | English |
|---|---|
| Pages (from-to) | 49-52 |
| Number of pages | 4 |
| Journal | Japanese Pharmacology and Therapeutics |
| Volume | 24 |
| Issue number | 1 |
| Publication status | Published - 1996 |
Fingerprint
Keywords
- Antiallergic drugs
- Histamine release
- Loratadine
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
Effect of loratadine on histamine release induced by antigen-antibody reaction. / Kamei, Chiaki; Sugimoto, Yukio; Yamaji, Masako; Takada, Miho.
In: Japanese Pharmacology and Therapeutics, Vol. 24, No. 1, 1996, p. 49-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of loratadine on histamine release induced by antigen-antibody reaction
AU - Kamei, Chiaki
AU - Sugimoto, Yukio
AU - Yamaji, Masako
AU - Takada, Miho
PY - 1996
Y1 - 1996
N2 - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.
AB - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.
KW - Antiallergic drugs
KW - Histamine release
KW - Loratadine
UR - http://www.scopus.com/inward/record.url?scp=0030062599&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030062599&partnerID=8YFLogxK
M3 - Article
VL - 24
SP - 49
EP - 52
JO - Japanese Pharmacology and Therapeutics
JF - Japanese Pharmacology and Therapeutics
SN - 0386-3603
IS - 1
ER -