Abstract
Royal jelly (RJ) is known to have abundant nutritional properties and a variety of biological activities. To investigate the effects of RJ on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetic model, were treated for 4 weeks with RJ (10, 30, and 300 mg/kg, p.o.). RJ treatment tended to decrease systolic blood pressure and significantly decreased serum levels of insulin and the Homeostasis Model Assessment ratio, an index of insulin resistance. In isolated and perfused mesenteric vascular beds of OLETF rats, RJ treatment resulted in significant reduction of the sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and potentiation of the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with that in untreated OLETF rats. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that RJ could be an effective and functional food to prevent the development of insulin resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 1877-1882 |
| Number of pages | 6 |
| Journal | Yakugaku Zasshi |
| Volume | 127 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2007 |
Fingerprint
Keywords
- Insulin resistance
- Otsuka Long-Evans Tokushima Fatty (OLETF) rats
- Periarterial nerve function
- Royal jelly
ASJC Scopus subject areas
- Molecular Medicine
Cite this
Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. / Nomura, Masataka; Maruo, Naomi; Zamami, Yoshito; Takatori, Shingo; Doi, Shima; Kawasaki, Hiromu.
In: Yakugaku Zasshi, Vol. 127, No. 11, 11.2007, p. 1877-1882.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
AU - Nomura, Masataka
AU - Maruo, Naomi
AU - Zamami, Yoshito
AU - Takatori, Shingo
AU - Doi, Shima
AU - Kawasaki, Hiromu
PY - 2007/11
Y1 - 2007/11
N2 - Royal jelly (RJ) is known to have abundant nutritional properties and a variety of biological activities. To investigate the effects of RJ on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetic model, were treated for 4 weeks with RJ (10, 30, and 300 mg/kg, p.o.). RJ treatment tended to decrease systolic blood pressure and significantly decreased serum levels of insulin and the Homeostasis Model Assessment ratio, an index of insulin resistance. In isolated and perfused mesenteric vascular beds of OLETF rats, RJ treatment resulted in significant reduction of the sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and potentiation of the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with that in untreated OLETF rats. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that RJ could be an effective and functional food to prevent the development of insulin resistance.
AB - Royal jelly (RJ) is known to have abundant nutritional properties and a variety of biological activities. To investigate the effects of RJ on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetic model, were treated for 4 weeks with RJ (10, 30, and 300 mg/kg, p.o.). RJ treatment tended to decrease systolic blood pressure and significantly decreased serum levels of insulin and the Homeostasis Model Assessment ratio, an index of insulin resistance. In isolated and perfused mesenteric vascular beds of OLETF rats, RJ treatment resulted in significant reduction of the sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and potentiation of the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with that in untreated OLETF rats. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that RJ could be an effective and functional food to prevent the development of insulin resistance.
KW - Insulin resistance
KW - Otsuka Long-Evans Tokushima Fatty (OLETF) rats
KW - Periarterial nerve function
KW - Royal jelly
UR - http://www.scopus.com/inward/record.url?scp=35949000948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35949000948&partnerID=8YFLogxK
U2 - 10.1248/yakushi.127.1877
DO - 10.1248/yakushi.127.1877
M3 - Article
VL - 127
SP - 1877
EP - 1882
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 11
ER -