Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats

Masataka Nomura, Naomi Maruo, Yoshito Zamami, Shingo Takatori, Shima Doi, Hiromu Kawasaki

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Royal jelly (RJ) is known to have abundant nutritional properties and a variety of biological activities. To investigate the effects of RJ on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetic model, were treated for 4 weeks with RJ (10, 30, and 300 mg/kg, p.o.). RJ treatment tended to decrease systolic blood pressure and significantly decreased serum levels of insulin and the Homeostasis Model Assessment ratio, an index of insulin resistance. In isolated and perfused mesenteric vascular beds of OLETF rats, RJ treatment resulted in significant reduction of the sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and potentiation of the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with that in untreated OLETF rats. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that RJ could be an effective and functional food to prevent the development of insulin resistance.

Original languageEnglish
Pages (from-to)1877-1882
Number of pages6
JournalYakugaku Zasshi
Volume127
Issue number11
DOIs
Publication statusPublished - Nov 1 2007

Keywords

  • Insulin resistance
  • Otsuka Long-Evans Tokushima Fatty (OLETF) rats
  • Periarterial nerve function
  • Royal jelly

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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