Effect of Long-Term Fluvoxamine Treatment on Endogenous Serotonin Uptake Inhibitor-Like Substance in Monkey Cerebrospinal Fluid

Toru Egashira, Shinichiro Goto, Yuji Wada, Fusako Takayama, Yasumitu Yamanaka

Research output: Contribution to journalArticle

Abstract

We found that substances present in monkey cerebrospinal fluid (CSF) could inhibit [3H]-paroxetine binding in monkey brain preparations. The molecular weight of one of these inhibitory substances was approximately 2000, which is in agreement with earlier studies using human CSF. We also found that the inhibitory effect of the substances present in monkey CSF on [3H]-paroxetine binding decreased after 8 weeks of chronic fluvoxamine (5 mg/kg day, p.o.) treatment. These results suggest that the ability of a drug to decrease the activity of endogenous 5-HT uptake modulators may related to its anti-depressive effects.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
Journalthe japanese journal of pharmacology
Volume67
Issue number2
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Keywords

  • 5-HT uptake inhibitor
  • Cerebrospinal fluid (monkey)
  • Fluvoxamine

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effect of Long-Term Fluvoxamine Treatment on Endogenous Serotonin Uptake Inhibitor-Like Substance in Monkey Cerebrospinal Fluid'. Together they form a unique fingerprint.

  • Cite this