Effect of long-term fluvoxamine treatment on endogenous serotonin uptake inhibitor-like substance in monkey cerebrospinal fluid

T. Egashira, S. Goto, Y. Wada, Fusako Takayama, Y. Yamanaka

Research output: Contribution to journalArticle

Abstract

We found that substances present in monkey cerebrospinal fluid (CSF) could inhibit [3H]-paroxetine binding in monkey brain preparations. The molecular weight of one of these inhibitory substances was approximately 2000, which is in agreement with earlier studies using human CSF. We also found that the inhibitory effect of the substances present in monkey CSF on [3H]-paroxetine binding decreased after 8 weeks of chronic fluvoxamine (5 mg/kg day, p.o.) treatment. These results suggest that the ability of a drug to decrease the activity of endogenous 5-HT uptake modulators may related to its antidepressive effects.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalJapanese Journal of Pharmacology
Volume67
Issue number2
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Fluvoxamine
Serotonin Uptake Inhibitors
Haplorhini
Cerebrospinal Fluid
Paroxetine
Serotonin
Molecular Weight
Brain
Pharmaceutical Preparations

Keywords

  • 5-HT uptake inhibitor
  • Cerebrospinal fluid (monkey)
  • Fluvoxamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of long-term fluvoxamine treatment on endogenous serotonin uptake inhibitor-like substance in monkey cerebrospinal fluid. / Egashira, T.; Goto, S.; Wada, Y.; Takayama, Fusako; Yamanaka, Y.

In: Japanese Journal of Pharmacology, Vol. 67, No. 2, 1995, p. 177-179.

Research output: Contribution to journalArticle

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