Effect of lipid amount on surfactant-free solid lipid nanoparticle formation by hot homogenization

Jun Oshitani, Natsumi Murakami, Mikio Yoshida, Naoyuki Ishida, Koreyoshi Imamura, Hideki Ichikawa

Research output: Contribution to journalArticle

Abstract

The yield and size distribution of surfactant-free solid lipid nanoparticles (SF-SLNs) formed by hot homogenization were investigated by changing the amount of lipid (palmitic acid). The yield was 100% and monodispersed same-sized particles of 120200nm were formed at the lipid amount ≤2.8 × 10-4 g-lipid (g-water)-1. The yield decreased owing to phase separation, and the size increased "step- likely" to be 200350nm while keeping the monodispersity when the lipid amount was just above ≤2.8 × 10-4 g-lipid (g-water) -1. The size and the lipid amount continued to increase gradually at the lipid amount >2.8 × 10-4 g-lipid (g-water)-1. The results indicate that submicron- sized solid lipid particles can be formed without surfactants and that the decrease of yield and the step-like increase of particle size occur at the same lipid amount. The total surface area of the SF-SLNs was estimated using the experimental data. It is suggested that the total surface area and the lipid amount are correlated to each other.

Original languageEnglish
Pages (from-to)1011-1013
Number of pages3
JournalChemistry Letters
Volume43
Issue number7
DOIs
Publication statusPublished - 2014

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Surface-Active Agents
Nanoparticles
Lipids
Water
Palmitic Acid
Phase separation
Particle size

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Effect of lipid amount on surfactant-free solid lipid nanoparticle formation by hot homogenization. / Oshitani, Jun; Murakami, Natsumi; Yoshida, Mikio; Ishida, Naoyuki; Imamura, Koreyoshi; Ichikawa, Hideki.

In: Chemistry Letters, Vol. 43, No. 7, 2014, p. 1011-1013.

Research output: Contribution to journalArticle

Oshitani, Jun ; Murakami, Natsumi ; Yoshida, Mikio ; Ishida, Naoyuki ; Imamura, Koreyoshi ; Ichikawa, Hideki. / Effect of lipid amount on surfactant-free solid lipid nanoparticle formation by hot homogenization. In: Chemistry Letters. 2014 ; Vol. 43, No. 7. pp. 1011-1013.
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AU - Ichikawa, Hideki

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AB - The yield and size distribution of surfactant-free solid lipid nanoparticles (SF-SLNs) formed by hot homogenization were investigated by changing the amount of lipid (palmitic acid). The yield was 100% and monodispersed same-sized particles of 120200nm were formed at the lipid amount ≤2.8 × 10-4 g-lipid (g-water)-1. The yield decreased owing to phase separation, and the size increased "step- likely" to be 200350nm while keeping the monodispersity when the lipid amount was just above ≤2.8 × 10-4 g-lipid (g-water) -1. The size and the lipid amount continued to increase gradually at the lipid amount >2.8 × 10-4 g-lipid (g-water)-1. The results indicate that submicron- sized solid lipid particles can be formed without surfactants and that the decrease of yield and the step-like increase of particle size occur at the same lipid amount. The total surface area of the SF-SLNs was estimated using the experimental data. It is suggested that the total surface area and the lipid amount are correlated to each other.

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