Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve

Toshikazu Nishimori, Tetsuya Ikeda, Ryuji Terayama, Yasushi Ishida, Tadashi Nakamura, Noriko Otahara

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6 Citations (Scopus)


Fos-like immunoreactivity (FLI) was investigated in the lumbar dorsal horn 2 h after transection of the rat sciatic nerve and sham operation. FLI following nerve transection was distributed through the medio-lateral extension of the superficial layer of the dorsal horn, while FLI after sham operation, tissue injury, was restricted to the lateral one-third of this layer. The number of FLI neurons in the lateral one-third was similar in the two operations, indicating that neurons expressing FLI in the medial two-thirds and in the lateral one-third of the superficial layer after nerve transection are derived from nerve injury and tissue injury, respectively. FLI in the lateral one-third, but not the medial two-thirds, after nerve transection was significantly reduced by pretreatment with NMDA and AMPA/KA receptor antagonists, indicating that there is a considerable difference in the contributions of ionotropic glutamate receptors to FLI in this layer induced by nerve injury and tissue injury.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalBrain Research
Issue number1
Publication statusPublished - Apr 26 2002
Externally publishedYes



  • CNQX
  • Dorsal horn neuron
  • Fos protein
  • MK-801
  • Nerve transection

ASJC Scopus subject areas

  • Neuroscience(all)

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