Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve

Toshikazu Nishimori, Tetsuya Ikeda, Ryuji Terayama, Yasushi Ishida, Tadashi Nakamura, Noriko Otahara

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fos-like immunoreactivity (FLI) was investigated in the lumbar dorsal horn 2 h after transection of the rat sciatic nerve and sham operation. FLI following nerve transection was distributed through the medio-lateral extension of the superficial layer of the dorsal horn, while FLI after sham operation, tissue injury, was restricted to the lateral one-third of this layer. The number of FLI neurons in the lateral one-third was similar in the two operations, indicating that neurons expressing FLI in the medial two-thirds and in the lateral one-third of the superficial layer after nerve transection are derived from nerve injury and tissue injury, respectively. FLI in the lateral one-third, but not the medial two-thirds, after nerve transection was significantly reduced by pretreatment with NMDA and AMPA/KA receptor antagonists, indicating that there is a considerable difference in the contributions of ionotropic glutamate receptors to FLI in this layer induced by nerve injury and tissue injury.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalBrain Research
Volume934
Issue number1
DOIs
Publication statusPublished - Apr 26 2002
Externally publishedYes

Fingerprint

Ionotropic Glutamate Receptors
Excitatory Amino Acid Antagonists
Sciatic Nerve
Wounds and Injuries
Nerve Tissue
Neurons
AMPA Receptors
N-Methylaspartate
Spinal Cord Dorsal Horn

Keywords

  • CNQX
  • Dorsal horn neuron
  • Fos protein
  • MK-801
  • Nerve transection

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve. / Nishimori, Toshikazu; Ikeda, Tetsuya; Terayama, Ryuji; Ishida, Yasushi; Nakamura, Tadashi; Otahara, Noriko.

In: Brain Research, Vol. 934, No. 1, 26.04.2002, p. 81-86.

Research output: Contribution to journalArticle

Nishimori, Toshikazu ; Ikeda, Tetsuya ; Terayama, Ryuji ; Ishida, Yasushi ; Nakamura, Tadashi ; Otahara, Noriko. / Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve. In: Brain Research. 2002 ; Vol. 934, No. 1. pp. 81-86.
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AU - Nakamura, Tadashi

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