Effect of hypoglycemic stress on the pars intermedia of the mouse pituitary gland: an ultrastructural analysis.

M. Takeuchi, S. Takahashi

Research output: Contribution to journalArticle

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Abstract

The present study was made to clarify the relationship between functions of the pars intermedia of the mouse pituitary gland and hypoglycemic stress. Morphometrical analysis of the ultrastructures of the pars intermedia cells showed (1) a rise in the percentage volume of rough endoplasmic reticulum (r-ER) indicative of an increase in protein synthesis, (2) an increase in the number of Golgi granules per unit Golgi area showing an induction of granule-forming activity and (3) a decrease in the numerical density of secretory granules reflecting a release of the secretory granules. These findings suggest that hypoglycemic stress induced by daily treatment with insulin or restriction of food intake was able to elicit heightened secretory activity of the pars intermedia cells of the mouse pituitary gland. However, acute hypoglycemic stress induced by food deprivation did not cytologically affect the pars intermedia. These observations suggest that repeated hypoglycemic stress, rather than acute hypoglycemic stress, may be a natural physiological stimulus of the pars intermedia of the mouse pituitary gland.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalZoological Science
Volume12
Issue number1
Publication statusPublished - Feb 1995

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glycemic effect
pituitary gland
secretory granules
granules
mice
food deprivation
rough endoplasmic reticulum
food intake
ultrastructure
insulin
protein synthesis
cells

ASJC Scopus subject areas

  • Animal Science and Zoology

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Effect of hypoglycemic stress on the pars intermedia of the mouse pituitary gland : an ultrastructural analysis. / Takeuchi, M.; Takahashi, S.

In: Zoological Science, Vol. 12, No. 1, 02.1995, p. 99-103.

Research output: Contribution to journalArticle

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