Histamine, 4-methylhistamine and dimaprit induced a dose-dependent increase in the cyclic AMP content of chopped canine parotid gland in the presence of 3-isobutyl-1-methylxanthine. Metiamide, but not mepyramine, inhibited the effect of these agonists dose-dependently. 2-(2-Pyridyl)ethylamine also increased the cyclic AMP content. This effect was completely blocked by propranolol. These results indicate that the cyclic AMP response to histamine in canine parotid gland is mediated by H2-receptors. Mepyramine enhanced the effect of histamine. A combination of aminoguanidine and quinacrine potentiated the effect of histamine, suggesting that there exist active histamine-metabolizing systems in canine parotid gland.
|Number of pages||7|
|Journal||Advances in the Biosciences|
|Publication status||Published - Dec 1 1982|
- cyclic AMP
- parotid gland