Abstract
To determine whether or not hepatoportal osmoreceptive (or sodium-receptive) signals participate in the control of drinking, we examined the effects of portal infusion of water, 0.9% saline, and 1.8% saline on water intake by water-deprived rats. Infusion was started 0.5 h prior to the end of the water deprivation period for 3.5 h at a rate of 52 μl/min through either a portal or a jugular catheter. After 24-h water deprivation, water intake was measured successively for 24 h without food. As a result of the water infusion tests, water intake of the portal infusion group was significantly less than that of the jugular infusion group during and after the infusion. Portal infusion of neither 0.9% nor 1.8% saline affected the water intake compared to similar infusion into the jugular vein. It is concluded that hypotonic stimulation of the hepatoportal osmoreceptor suppresses water intake in water-deprived rats. On the contrary, isotonic or hypertonic stimulation does not produce any change of water intake.
| Original language | English |
|---|---|
| Pages (from-to) | 885-888 |
| Number of pages | 4 |
| Journal | Physiology and Behavior |
| Volume | 52 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1992 |
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Keywords
- Drinking
- Hepatic
- Infusion
- Osmoreceptor
- Portal
- Rat
- Water deprivation
- Water intake
ASJC Scopus subject areas
- Physiology (medical)
- Behavioral Neuroscience
Cite this
Effect of hepatic portal infusion of water on water intake by water-deprived rats. / Kobashi, Motoi; Adachi, Akira.
In: Physiology and Behavior, Vol. 52, No. 5, 1992, p. 885-888.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of hepatic portal infusion of water on water intake by water-deprived rats
AU - Kobashi, Motoi
AU - Adachi, Akira
PY - 1992
Y1 - 1992
N2 - To determine whether or not hepatoportal osmoreceptive (or sodium-receptive) signals participate in the control of drinking, we examined the effects of portal infusion of water, 0.9% saline, and 1.8% saline on water intake by water-deprived rats. Infusion was started 0.5 h prior to the end of the water deprivation period for 3.5 h at a rate of 52 μl/min through either a portal or a jugular catheter. After 24-h water deprivation, water intake was measured successively for 24 h without food. As a result of the water infusion tests, water intake of the portal infusion group was significantly less than that of the jugular infusion group during and after the infusion. Portal infusion of neither 0.9% nor 1.8% saline affected the water intake compared to similar infusion into the jugular vein. It is concluded that hypotonic stimulation of the hepatoportal osmoreceptor suppresses water intake in water-deprived rats. On the contrary, isotonic or hypertonic stimulation does not produce any change of water intake.
AB - To determine whether or not hepatoportal osmoreceptive (or sodium-receptive) signals participate in the control of drinking, we examined the effects of portal infusion of water, 0.9% saline, and 1.8% saline on water intake by water-deprived rats. Infusion was started 0.5 h prior to the end of the water deprivation period for 3.5 h at a rate of 52 μl/min through either a portal or a jugular catheter. After 24-h water deprivation, water intake was measured successively for 24 h without food. As a result of the water infusion tests, water intake of the portal infusion group was significantly less than that of the jugular infusion group during and after the infusion. Portal infusion of neither 0.9% nor 1.8% saline affected the water intake compared to similar infusion into the jugular vein. It is concluded that hypotonic stimulation of the hepatoportal osmoreceptor suppresses water intake in water-deprived rats. On the contrary, isotonic or hypertonic stimulation does not produce any change of water intake.
KW - Drinking
KW - Hepatic
KW - Infusion
KW - Osmoreceptor
KW - Portal
KW - Rat
KW - Water deprivation
KW - Water intake
UR - http://www.scopus.com/inward/record.url?scp=0026453013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026453013&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(92)90366-A
DO - 10.1016/0031-9384(92)90366-A
M3 - Article
C2 - 1484844
AN - SCOPUS:0026453013
VL - 52
SP - 885
EP - 888
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 5
ER -