Effect of hepatic portal infusion of water on water intake by water-deprived rats

Motoi Kobashi, Akira Adachi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


To determine whether or not hepatoportal osmoreceptive (or sodium-receptive) signals participate in the control of drinking, we examined the effects of portal infusion of water, 0.9% saline, and 1.8% saline on water intake by water-deprived rats. Infusion was started 0.5 h prior to the end of the water deprivation period for 3.5 h at a rate of 52 μl/min through either a portal or a jugular catheter. After 24-h water deprivation, water intake was measured successively for 24 h without food. As a result of the water infusion tests, water intake of the portal infusion group was significantly less than that of the jugular infusion group during and after the infusion. Portal infusion of neither 0.9% nor 1.8% saline affected the water intake compared to similar infusion into the jugular vein. It is concluded that hypotonic stimulation of the hepatoportal osmoreceptor suppresses water intake in water-deprived rats. On the contrary, isotonic or hypertonic stimulation does not produce any change of water intake.

Original languageEnglish
Pages (from-to)885-888
Number of pages4
JournalPhysiology and Behavior
Issue number5
Publication statusPublished - Nov 1992


  • Drinking
  • Hepatic
  • Infusion
  • Osmoreceptor
  • Portal
  • Rat
  • Water deprivation
  • Water intake

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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