Effect of glycyrrhizin on monoamine dynamics in the rat brain

T. Egashira, F. Takayama, Y. Yamanaka, K. Takada, H. Takeda, T. Matsumiya

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of glycyrrhizin on the amine dynamics in noradrenergic, dopaminergic or serotonergic nervous system in the rat brain was investigated. Following repeated subcutaneous administration of glycyrrhizin 50mg/kg for 7 days, significant decreases in the 4-hydroxy-3-methoxy- phenylglycol(MHPG)/norepinephrine(NE) ratio in the hippocampus and hypothalamus were produced. Glycyrrhizin 50 mg/kg s.c. also caused a significant decrease in 3,4-dihydroxyphenylacetic acid(DOPAC)/dopamine (DA) ratio in the hippocampus. But, Glycyrrhizin did not induced significant changes in 5-hydroxyindole-3 acetic acid (5-HIAA)/serotonin (5-HT) ratio in 4 regions of the brain. These findings suggest that hight doses of glycyrrhizin decreases NE or DA turnover in hippocampus and hypothalamus as a result of the interference with the NE or DA content in the neuron, but therapeutic doses of glycyrrhizin dose not cause a significant change on monoamine turnover in the brain.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalJapanese Pharmacology and Therapeutics
Volume27
Issue number4
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Glycyrrhizin
  • Monoamine
  • Rat brain
  • Turnover

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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