Effect of glycyrrhizin on monoamine dynamics in the rat brain

T. Egashira, Fusako Takayama, Y. Yamanaka, K. Takada, H. Takeda, T. Matsumiya

Research output: Contribution to journalArticle

Abstract

The effect of glycyrrhizin on the amine dynamics in noradrenergic, dopaminergic or serotonergic nervous system in the rat brain was investigated. Following repeated subcutaneous administration of glycyrrhizin 50mg/kg for 7 days, significant decreases in the 4-hydroxy-3-methoxy- phenylglycol(MHPG)/norepinephrine(NE) ratio in the hippocampus and hypothalamus were produced. Glycyrrhizin 50 mg/kg s.c. also caused a significant decrease in 3,4-dihydroxyphenylacetic acid(DOPAC)/dopamine (DA) ratio in the hippocampus. But, Glycyrrhizin did not induced significant changes in 5-hydroxyindole-3 acetic acid (5-HIAA)/serotonin (5-HT) ratio in 4 regions of the brain. These findings suggest that hight doses of glycyrrhizin decreases NE or DA turnover in hippocampus and hypothalamus as a result of the interference with the NE or DA content in the neuron, but therapeutic doses of glycyrrhizin dose not cause a significant change on monoamine turnover in the brain.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalJapanese Pharmacology and Therapeutics
Volume27
Issue number4
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Glycyrrhizic Acid
Brain
Hippocampus
Dopamine
Norepinephrine
Hypothalamus
Methoxyhydroxyphenylglycol
3,4-Dihydroxyphenylacetic Acid
Acetic Acid
Nervous System
Amines
Serotonin
Neurons

Keywords

  • Glycyrrhizin
  • Monoamine
  • Rat brain
  • Turnover

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Egashira, T., Takayama, F., Yamanaka, Y., Takada, K., Takeda, H., & Matsumiya, T. (1999). Effect of glycyrrhizin on monoamine dynamics in the rat brain. Japanese Pharmacology and Therapeutics, 27(4), 171-175.

Effect of glycyrrhizin on monoamine dynamics in the rat brain. / Egashira, T.; Takayama, Fusako; Yamanaka, Y.; Takada, K.; Takeda, H.; Matsumiya, T.

In: Japanese Pharmacology and Therapeutics, Vol. 27, No. 4, 1999, p. 171-175.

Research output: Contribution to journalArticle

Egashira, T, Takayama, F, Yamanaka, Y, Takada, K, Takeda, H & Matsumiya, T 1999, 'Effect of glycyrrhizin on monoamine dynamics in the rat brain', Japanese Pharmacology and Therapeutics, vol. 27, no. 4, pp. 171-175.
Egashira T, Takayama F, Yamanaka Y, Takada K, Takeda H, Matsumiya T. Effect of glycyrrhizin on monoamine dynamics in the rat brain. Japanese Pharmacology and Therapeutics. 1999;27(4):171-175.
Egashira, T. ; Takayama, Fusako ; Yamanaka, Y. ; Takada, K. ; Takeda, H. ; Matsumiya, T. / Effect of glycyrrhizin on monoamine dynamics in the rat brain. In: Japanese Pharmacology and Therapeutics. 1999 ; Vol. 27, No. 4. pp. 171-175.
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