Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats

Yoichi Kawasaki, Chunyu Jin, Katsuya Suemaru, Hiromu Kawasaki, Kazuhiko Shibata, Tominari Choshi, Satoshi Hibino, Yutaka Gomita, Hiroaki Araki

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The neurobiological mechanism underlying the negative motivational component of withdrawal from acute opiate dependence is far from understood. Our objectives were to determine whether the glutamatergic system is involved in the motivational component of morphine withdrawal in acutely dependent rats and such an involvement is associated with dopaminergic neurotransmission. We examined the effects of various kinds of glutamate receptor antagonists on conditioned place aversion (CPA) induced by naloxone-precipitated withdrawal from a single morphine exposure 24 h before. Furthermore, the influence of pretreatment with the dopamine receptor antagonist haloperidol on those effects of glutamate receptor antagonists was also investigated. CPA was attenuated in a dose-dependent manner by all glutamate receptor antagonists examined including the NMDA receptor antagonists (+)-5-methyl-10,11 -dihydro-5H-dibenzo[a,d]cyclo- hepten-5,10-imine maleate (MK-801) and phencyclidine hydrochloride (PCP), AMPA receptor antagonist 1-(4-aminophenyl)4-methyl-7,8-methylenedioxy-5H-2,3- benzodiazepine hydrochloride (GYKI 52466), and metabotropic receptor antagonists (±)-2-amino-3-phosphonopropionic acid (AP-3) and (±)-α- methyl-4-carboxyphenylglycine (4MCPG). The effects of MK-801, GYKI 52466 and MCPG were blocked by haloperidol. These results suggest that the glutamatergic system involving multiple classes of receptors plays a role in the motivational component of withdrawal from acute morphine dependence, and the function of the glutamatergic system would be closely associated with dopaminergic neurotransmission.

Original languageEnglish
Pages (from-to)751-757
Number of pages7
JournalBritish Journal of Pharmacology
Volume145
Issue number6
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Excitatory Amino Acid Antagonists
Naloxone
Morphine
Dizocilpine Maleate
Haloperidol
GYKI 53655
Synaptic Transmission
Phencyclidine Receptors
Morphine Dependence
Opioid-Related Disorders
Phencyclidine
Imines
AMPA Receptors
Dopamine Antagonists
N-Methyl-D-Aspartate Receptors
GYKI 52466

Keywords

  • Acute dependence
  • Conditioned place aversion
  • Dopamine
  • Glutamate receptor antagonist
  • Morphine
  • Naloxone
  • Withdrawal

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats. / Kawasaki, Yoichi; Jin, Chunyu; Suemaru, Katsuya; Kawasaki, Hiromu; Shibata, Kazuhiko; Choshi, Tominari; Hibino, Satoshi; Gomita, Yutaka; Araki, Hiroaki.

In: British Journal of Pharmacology, Vol. 145, No. 6, 07.2005, p. 751-757.

Research output: Contribution to journalArticle

Kawasaki, Y, Jin, C, Suemaru, K, Kawasaki, H, Shibata, K, Choshi, T, Hibino, S, Gomita, Y & Araki, H 2005, 'Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats', British Journal of Pharmacology, vol. 145, no. 6, pp. 751-757. https://doi.org/10.1038/sj.bjp.0706228
Kawasaki, Yoichi ; Jin, Chunyu ; Suemaru, Katsuya ; Kawasaki, Hiromu ; Shibata, Kazuhiko ; Choshi, Tominari ; Hibino, Satoshi ; Gomita, Yutaka ; Araki, Hiroaki. / Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats. In: British Journal of Pharmacology. 2005 ; Vol. 145, No. 6. pp. 751-757.
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