Abstract
It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.
Original language | English |
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Pages (from-to) | 91-95 |
Number of pages | 5 |
Journal | Japanese Pharmacology and Therapeutics |
Volume | 30 |
Issue number | 2 |
Publication status | Published - Jan 1 2002 |
Keywords
- Active avoidance response
- H-antagonists
- Learning and memory
- Second generation
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)