Abstract
It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 91-95 |
| Number of pages | 5 |
| Journal | Japanese Pharmacology and Therapeutics |
| Volume | 30 |
| Issue number | 2 |
| Publication status | Published - 2002 |
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Keywords
- Active avoidance response
- H-antagonists
- Learning and memory
- Second generation
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
Effect of epinastine hydrochloride (Alesion®) on the central nervous system. / Kamei, Chiaki; Nishiga, Miyuki; Shigemoto, Yuki; Konishi, Masako; Shinomiya, Kazuaki.
In: Japanese Pharmacology and Therapeutics, Vol. 30, No. 2, 2002, p. 91-95.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of epinastine hydrochloride (Alesion®) on the central nervous system
AU - Kamei, Chiaki
AU - Nishiga, Miyuki
AU - Shigemoto, Yuki
AU - Konishi, Masako
AU - Shinomiya, Kazuaki
PY - 2002
Y1 - 2002
N2 - It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.
AB - It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.
KW - Active avoidance response
KW - H-antagonists
KW - Learning and memory
KW - Second generation
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UR - http://www.scopus.com/inward/citedby.url?scp=0036034086&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0036034086
VL - 30
SP - 91
EP - 95
JO - Japanese Pharmacology and Therapeutics
JF - Japanese Pharmacology and Therapeutics
SN - 0386-3603
IS - 2
ER -