Effect of epinastine hydrochloride (Alesion®) on the central nervous system

Chiaki Kamei, Miyuki Nishiga, Yuki Shigemoto, Masako Konishi, Kazuaki Shinomiya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalJapanese Pharmacology and Therapeutics
Volume30
Issue number2
Publication statusPublished - 2002

Fingerprint

Ketotifen
Central Nervous System
Sleep
Anti-Allergic Agents
Sleep Stages
Reaction Time
Fatigue
epinastine
Pharmaceutical Preparations
Olopatadine Hydrochloride

Keywords

  • Active avoidance response
  • H-antagonists
  • Learning and memory
  • Second generation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Kamei, C., Nishiga, M., Shigemoto, Y., Konishi, M., & Shinomiya, K. (2002). Effect of epinastine hydrochloride (Alesion®) on the central nervous system. Japanese Pharmacology and Therapeutics, 30(2), 91-95.

Effect of epinastine hydrochloride (Alesion®) on the central nervous system. / Kamei, Chiaki; Nishiga, Miyuki; Shigemoto, Yuki; Konishi, Masako; Shinomiya, Kazuaki.

In: Japanese Pharmacology and Therapeutics, Vol. 30, No. 2, 2002, p. 91-95.

Research output: Contribution to journalArticle

Kamei, C, Nishiga, M, Shigemoto, Y, Konishi, M & Shinomiya, K 2002, 'Effect of epinastine hydrochloride (Alesion®) on the central nervous system', Japanese Pharmacology and Therapeutics, vol. 30, no. 2, pp. 91-95.
Kamei C, Nishiga M, Shigemoto Y, Konishi M, Shinomiya K. Effect of epinastine hydrochloride (Alesion®) on the central nervous system. Japanese Pharmacology and Therapeutics. 2002;30(2):91-95.
Kamei, Chiaki ; Nishiga, Miyuki ; Shigemoto, Yuki ; Konishi, Masako ; Shinomiya, Kazuaki. / Effect of epinastine hydrochloride (Alesion®) on the central nervous system. In: Japanese Pharmacology and Therapeutics. 2002 ; Vol. 30, No. 2. pp. 91-95.
@article{f033a117ebd14393a15ea663cfcc7f83,
title = "Effect of epinastine hydrochloride (Alesion{\circledR}) on the central nervous system",
abstract = "It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.",
keywords = "Active avoidance response, H-antagonists, Learning and memory, Second generation",
author = "Chiaki Kamei and Miyuki Nishiga and Yuki Shigemoto and Masako Konishi and Kazuaki Shinomiya",
year = "2002",
language = "English",
volume = "30",
pages = "91--95",
journal = "Japanese Pharmacology and Therapeutics",
issn = "0386-3603",
publisher = "Life Science Publishing Co. Ltd",
number = "2",

}

TY - JOUR

T1 - Effect of epinastine hydrochloride (Alesion®) on the central nervous system

AU - Kamei, Chiaki

AU - Nishiga, Miyuki

AU - Shigemoto, Yuki

AU - Konishi, Masako

AU - Shinomiya, Kazuaki

PY - 2002

Y1 - 2002

N2 - It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.

AB - It has been reported that epinastine showed less side effects such as drowsiness and lassitude compared with those of other anti-allergic drugs. To clarify these findings, effect of epinastine on sleep latency and active avoidance response in rats was studied in comparison with those of olopatadine and ketotifen. As a results, epinastine caused no decrease in sleep latency even at a dose of 50 mg/kg, p.o. In contrast, olopatadine at 50 mg/kg and ketotifen at 10 mg/kg caused a significant decrease in sleep latency. On the other hand, epinastine at 50 mg/kg showed no significant effect on active avoidance response. Olopatadine and ketotifen caused a significant prolongation of avoidance response latency, at 20 mg/kg and 10 mg/kg, respectively.

KW - Active avoidance response

KW - H-antagonists

KW - Learning and memory

KW - Second generation

UR - http://www.scopus.com/inward/record.url?scp=0036034086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036034086&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0036034086

VL - 30

SP - 91

EP - 95

JO - Japanese Pharmacology and Therapeutics

JF - Japanese Pharmacology and Therapeutics

SN - 0386-3603

IS - 2

ER -