Effect of embryonic hippocampal transplantation in amygdaloid kindled rat

Osamu Miyamoto, Toshifumi Itano, Yoshitaka Yamamoto, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Hiroshi Suwaki, Yasushi Okada, Tetuhide H. Murakami, Tetsuro Negi, Sukita Nakahara, Osamu Hatase

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalBrain Research
Volume603
Issue number1
DOIs
Publication statusPublished - Feb 12 1993
Externally publishedYes

Fingerprint

Transplantation
Cell Transplantation
Hippocampus
Suspensions
Seizures
Transplants
Injections
Therapeutics
Drug Resistant Epilepsy

Keywords

  • Epilepsy
  • Hippocampus
  • Kindling
  • Transplantation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Miyamoto, O., Itano, T., Yamamoto, Y., Tokuda, M., Matsui, H., Janjua, N. A., ... Hatase, O. (1993). Effect of embryonic hippocampal transplantation in amygdaloid kindled rat. Brain Research, 603(1), 143-147. https://doi.org/10.1016/0006-8993(93)91312-G

Effect of embryonic hippocampal transplantation in amygdaloid kindled rat. / Miyamoto, Osamu; Itano, Toshifumi; Yamamoto, Yoshitaka; Tokuda, Masaaki; Matsui, Hideki; Janjua, Najma A.; Suwaki, Hiroshi; Okada, Yasushi; Murakami, Tetuhide H.; Negi, Tetsuro; Nakahara, Sukita; Hatase, Osamu.

In: Brain Research, Vol. 603, No. 1, 12.02.1993, p. 143-147.

Research output: Contribution to journalArticle

Miyamoto, O, Itano, T, Yamamoto, Y, Tokuda, M, Matsui, H, Janjua, NA, Suwaki, H, Okada, Y, Murakami, TH, Negi, T, Nakahara, S & Hatase, O 1993, 'Effect of embryonic hippocampal transplantation in amygdaloid kindled rat', Brain Research, vol. 603, no. 1, pp. 143-147. https://doi.org/10.1016/0006-8993(93)91312-G
Miyamoto O, Itano T, Yamamoto Y, Tokuda M, Matsui H, Janjua NA et al. Effect of embryonic hippocampal transplantation in amygdaloid kindled rat. Brain Research. 1993 Feb 12;603(1):143-147. https://doi.org/10.1016/0006-8993(93)91312-G
Miyamoto, Osamu ; Itano, Toshifumi ; Yamamoto, Yoshitaka ; Tokuda, Masaaki ; Matsui, Hideki ; Janjua, Najma A. ; Suwaki, Hiroshi ; Okada, Yasushi ; Murakami, Tetuhide H. ; Negi, Tetsuro ; Nakahara, Sukita ; Hatase, Osamu. / Effect of embryonic hippocampal transplantation in amygdaloid kindled rat. In: Brain Research. 1993 ; Vol. 603, No. 1. pp. 143-147.
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