Effect of embryonic hippocampal transplantation in amygdaloid kindled rat

Osamu Miyamoto, Toshifumi Itano, Yoshitaka Yamamoto, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Hiroshi Suwaki, Yasushi Okada, Tetuhide H. Murakami, Tetsuro Negi, Sukita Nakahara, Osamu Hatase

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalBrain Research
Volume603
Issue number1
DOIs
Publication statusPublished - Feb 12 1993

Keywords

  • Epilepsy
  • Hippocampus
  • Kindling
  • Transplantation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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