Effect of embryonic hippocampal transplantation in amygdaloid kindled rat

Osamu Miyamoto; Toshifumi Itano; Yoshitaka Yamamoto; Masaaki Tokuda; Hideki Matsui; Najma A. Janjua; Hiroshi Suwaki; Yasushi Okada; Tetuhide H. Murakami; Tetsuro Negi; Sukita Nakahara; Osamu Hatase

doi:10.1016/0006-8993(93)91312-G

Effect of embryonic hippocampal transplantation in amygdaloid kindled rat

Osamu Miyamoto, Toshifumi Itano, Yoshitaka Yamamoto, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Hiroshi Suwaki, Yasushi Okada, Tetuhide H. Murakami, Tetsuro Negi, Sukita Nakahara, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	Brain Research
Volume	603
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)91312-G
Publication status	Published - Feb 12 1993

Keywords

Epilepsy
Hippocampus
Kindling
Transplantation

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)91312-G

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title = "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat",

abstract = "Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.",

keywords = "Epilepsy, Hippocampus, Kindling, Transplantation",

author = "Osamu Miyamoto and Toshifumi Itano and Yoshitaka Yamamoto and Masaaki Tokuda and Hideki Matsui and Janjua, {Najma A.} and Hiroshi Suwaki and Yasushi Okada and Murakami, {Tetuhide H.} and Tetsuro Negi and Sukita Nakahara and Osamu Hatase",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science and Culture of Japan, and by a Grant from the Japan Epilepsy Research Foundation.",

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doi = "10.1016/0006-8993(93)91312-G",

language = "English",

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T1 - Effect of embryonic hippocampal transplantation in amygdaloid kindled rat

AU - Miyamoto, Osamu

AU - Itano, Toshifumi

AU - Yamamoto, Yoshitaka

AU - Tokuda, Masaaki

AU - Matsui, Hideki

AU - Janjua, Najma A.

AU - Suwaki, Hiroshi

AU - Okada, Yasushi

AU - Murakami, Tetuhide H.

AU - Negi, Tetsuro

AU - Nakahara, Sukita

AU - Hatase, Osamu

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science and Culture of Japan, and by a Grant from the Japan Epilepsy Research Foundation.

PY - 1993/2/12

Y1 - 1993/2/12

N2 - Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.

AB - Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.

KW - Epilepsy

KW - Hippocampus

KW - Kindling

KW - Transplantation

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JF - Molecular Brain Research

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ER -

Effect of embryonic hippocampal transplantation in amygdaloid kindled rat

Abstract

Keywords

ASJC Scopus subject areas

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