Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells

Shunji Hayashi, Toshiro Sugiyama, Akira Yachi, Kenji Yokota, Yoshikazu Hirai, Keiji Oguma, Nobuhiro Fujii

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.

Original languageEnglish
Pages (from-to)593-597
Number of pages5
JournalJournal of Gastroenterology
Volume32
Issue number5
Publication statusPublished - Oct 1997

Fingerprint

Helicobacter pylori
Stomach
Epithelial Cells
Helicobacter Infections
ecabet
Enzyme-Linked Immunosorbent Assay

Keywords

  • Adhesion
  • Ecabet sodium
  • Gastric epithelial cells
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hayashi, S., Sugiyama, T., Yachi, A., Yokota, K., Hirai, Y., Oguma, K., & Fujii, N. (1997). Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells. Journal of Gastroenterology, 32(5), 593-597.

Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells. / Hayashi, Shunji; Sugiyama, Toshiro; Yachi, Akira; Yokota, Kenji; Hirai, Yoshikazu; Oguma, Keiji; Fujii, Nobuhiro.

In: Journal of Gastroenterology, Vol. 32, No. 5, 10.1997, p. 593-597.

Research output: Contribution to journalArticle

Hayashi, S, Sugiyama, T, Yachi, A, Yokota, K, Hirai, Y, Oguma, K & Fujii, N 1997, 'Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells', Journal of Gastroenterology, vol. 32, no. 5, pp. 593-597.
Hayashi S, Sugiyama T, Yachi A, Yokota K, Hirai Y, Oguma K et al. Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells. Journal of Gastroenterology. 1997 Oct;32(5):593-597.
Hayashi, Shunji ; Sugiyama, Toshiro ; Yachi, Akira ; Yokota, Kenji ; Hirai, Yoshikazu ; Oguma, Keiji ; Fujii, Nobuhiro. / Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells. In: Journal of Gastroenterology. 1997 ; Vol. 32, No. 5. pp. 593-597.
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