Effect of ecabet sodium on Helicobacter pylori adhesion to gastric epithelial cells

Shunji Hayashi, Toshiro Sugiyama, Akira Yachi, Kenji Yokota, Yoshikazu Hirai, Keiji Oguma, Nobuhiro Fujii

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Helicobacter pylori is a major etiological agent in gastroduodenal disorders, with the adhesion of H. pylori to gastric epithelial cells being the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in preventing H. pylori infection. We evaluated the effect of ecabet sodium, an antiulcer agent, on H. pylori adhesion to gastric epithelial cells, using our previously established enzyme-linked immunosorbent assay. The adhesion of H. pylori was significantly inhibited by ecabet sodium in a dose-dependent manner. Our studies suggest that ecabet sodium inhibits the adhesion of H. pylori to gastric epithelial cells.

Original languageEnglish
Pages (from-to)593-597
Number of pages5
JournalJournal of Gastroenterology
Volume32
Issue number5
DOIs
Publication statusPublished - Oct 1997

Keywords

  • Adhesion
  • Ecabet sodium
  • Gastric epithelial cells
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology

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