Effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction - The OACIS-LIPID study

Hiroshi Sato, Kunihiro Kinjo, Hiroshi Ito, Atsushi Hirayama, Shinsuke Nanto, Masatake Fukunami, Masami Nishino, Young Jae Lim, Yoshiyuki Kijima, Yukihiro Koretsune, Daisaku Nakatani, Hiroya Mizuno, Masahiko Shimizu, Masatsugu Hori

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Abstract

Background: It is unclear whether early initiation of low-dose pravastatin therapy can reduce the occurrence of major adverse cardiac events after acute myocardial infarction (AMI). Methods and Results: The study group comprised 353 patients with AMI who had plasma total cholesterol levels of 200-250mg/dl and triglyceride levels <300mg/dl. The patients were randomly assigned to either receive pravastatin (10mg/daily, n=176) or not (n=177). The primary endpoint was a composite of death, nonfatal myocardial infarction (MI), unstable angina (UA), stroke, revascularization, and rehospitalization because of other cardiovascular disease. The follow-up period was 9 months. The primary endpoint occurred in 31 patients (17.9%) in the pravastatin group and 55 patients (31.4%) in the non-pravastatin group (relative risk, 0.56; 95% confidence interval, 0.36-0.87). There were no significant differences in the risk of death, nonfatal MI, UA, and stroke between the 2 groups, although the pravastatin group had a lower risk of need for revascularization. Conclusion: For patients with AMI, early and low-dose pravastatin therapy (10mg/daily) reduces recurrent major adverse cardiac events, mostly the requirement for revascularization.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalCirculation Journal
Volume72
Issue number1
DOIs
Publication statusPublished - Mar 27 2008

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Keywords

  • Myocardial infarction
  • Prevention
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sato, H., Kinjo, K., Ito, H., Hirayama, A., Nanto, S., Fukunami, M., Nishino, M., Lim, Y. J., Kijima, Y., Koretsune, Y., Nakatani, D., Mizuno, H., Shimizu, M., & Hori, M. (2008). Effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction - The OACIS-LIPID study. Circulation Journal, 72(1), 17-22. https://doi.org/10.1253/circj.72.17