Effect of Doxorubicin Release Rate From Polyethylene Glycol-Modified Liposome on Anti-tumor Activity in B16-BL6 Tumor-Bearing Mice

Masato Maruyama, Haruka Tojo, Keita Toi, Yusuke Ienaka, Kenji Hyodo, Hiroshi Kikuchi, Ken-ichi Ogawara, Kazutaka Higaki

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate the effect of doxorubicin (DOX) release rates from polyethylene glycol (PEG)-liposomes on the anti-tumor activity, several in-vitro and in-vivo studies were performed by utilizing three types of DOX-PEG-liposomes showing the slow (L-Slow), middle (L-Mid) and fast (L-Fast) release rates of DOX. L-Mid provided the highest anti-tumor activity in B16-BL6 tumor-bearing mice, although the largest amount of DOX distribution into the tumor tissue was observed in L-Slow-administered mice and the lowest was in L-Fast-administered mice. To elucidate the reason for this discrepancy, DOX distribution into cancer cells constituting the tumor tissue was determined and the highest DOX distribution into cancer cells was observed in L-Mid-administered mice. These results clearly indicate that the adequate drug release rate from liposome should make it possible to deliver the substantial amounts of drugs into cancer cells, leading to the actual anti-tumor activity.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume111
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Cancer chemotherapy
  • Drug delivery system
  • Drug targeting
  • Liposome
  • Nanoparticle
  • Polyethylene glycol

ASJC Scopus subject areas

  • Pharmaceutical Science

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