Effect of donor preservation solution and survival in lung transplantation

Silvana F. Marasco, Michael Bailey, Daniel McGlade, Greg Snell, Glen Westall, Takahiro Oto, David Pilcher

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. Methods: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. Results: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). Conclusion: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.

Original languageEnglish
Pages (from-to)414-419
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

Fingerprint

Lung Transplantation
Primary Graft Dysfunction
Tissue Donors
Survival
Mortality
Odds Ratio
Lung
Organ Preservation Solutions
Propensity Score
Multivariate Analysis
Retrospective Studies
Transplants
Incidence

Keywords

  • donor management
  • lung transplantation
  • preservation solution
  • reperfusion injury

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Effect of donor preservation solution and survival in lung transplantation. / Marasco, Silvana F.; Bailey, Michael; McGlade, Daniel; Snell, Greg; Westall, Glen; Oto, Takahiro; Pilcher, David.

In: Journal of Heart and Lung Transplantation, Vol. 30, No. 4, 04.2011, p. 414-419.

Research output: Contribution to journalArticle

Marasco, Silvana F. ; Bailey, Michael ; McGlade, Daniel ; Snell, Greg ; Westall, Glen ; Oto, Takahiro ; Pilcher, David. / Effect of donor preservation solution and survival in lung transplantation. In: Journal of Heart and Lung Transplantation. 2011 ; Vol. 30, No. 4. pp. 414-419.
@article{1efb12f40d4b4285bd863127dcdf3c20,
title = "Effect of donor preservation solution and survival in lung transplantation",
abstract = "Background: The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. Methods: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. Results: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). Conclusion: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.",
keywords = "donor management, lung transplantation, preservation solution, reperfusion injury",
author = "Marasco, {Silvana F.} and Michael Bailey and Daniel McGlade and Greg Snell and Glen Westall and Takahiro Oto and David Pilcher",
year = "2011",
month = "4",
doi = "10.1016/j.healun.2010.10.002",
language = "English",
volume = "30",
pages = "414--419",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Effect of donor preservation solution and survival in lung transplantation

AU - Marasco, Silvana F.

AU - Bailey, Michael

AU - McGlade, Daniel

AU - Snell, Greg

AU - Westall, Glen

AU - Oto, Takahiro

AU - Pilcher, David

PY - 2011/4

Y1 - 2011/4

N2 - Background: The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. Methods: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. Results: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). Conclusion: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.

AB - Background: The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. Methods: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. Results: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). Conclusion: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.

KW - donor management

KW - lung transplantation

KW - preservation solution

KW - reperfusion injury

UR - http://www.scopus.com/inward/record.url?scp=79952748050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952748050&partnerID=8YFLogxK

U2 - 10.1016/j.healun.2010.10.002

DO - 10.1016/j.healun.2010.10.002

M3 - Article

C2 - 21131216

AN - SCOPUS:79952748050

VL - 30

SP - 414

EP - 419

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 4

ER -