Abstract
Background: The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. Methods: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. Results: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). Conclusion: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.
| Original language | English |
|---|---|
| Pages (from-to) | 414-419 |
| Number of pages | 6 |
| Journal | Journal of Heart and Lung Transplantation |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2011 |
| Externally published | Yes |
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Keywords
- donor management
- lung transplantation
- preservation solution
- reperfusion injury
ASJC Scopus subject areas
- Transplantation
- Cardiology and Cardiovascular Medicine
- Pulmonary and Respiratory Medicine
- Surgery
Cite this
Effect of donor preservation solution and survival in lung transplantation. / Marasco, Silvana F.; Bailey, Michael; McGlade, Daniel; Snell, Greg; Westall, Glen; Oto, Takahiro; Pilcher, David.
In: Journal of Heart and Lung Transplantation, Vol. 30, No. 4, 04.2011, p. 414-419.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of donor preservation solution and survival in lung transplantation
AU - Marasco, Silvana F.
AU - Bailey, Michael
AU - McGlade, Daniel
AU - Snell, Greg
AU - Westall, Glen
AU - Oto, Takahiro
AU - Pilcher, David
PY - 2011/4
Y1 - 2011/4
N2 - Background: The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. Methods: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. Results: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). Conclusion: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.
AB - Background: The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. Methods: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. Results: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). Conclusion: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.
KW - donor management
KW - lung transplantation
KW - preservation solution
KW - reperfusion injury
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UR - http://www.scopus.com/inward/citedby.url?scp=79952748050&partnerID=8YFLogxK
U2 - 10.1016/j.healun.2010.10.002
DO - 10.1016/j.healun.2010.10.002
M3 - Article
C2 - 21131216
AN - SCOPUS:79952748050
VL - 30
SP - 414
EP - 419
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
SN - 1053-2498
IS - 4
ER -