Effect of donor pre-mortem hypoxia and hypotension on graft function and start of warm ischemia in donation after cardiac death lung transplantation

Kentaroh Miyoshi, Takahiro Oto, Shinji Otani, Shin Tanaka, Masaaki Harada, Tomokazu Kakishita, Shiro Hori, Naohisa Waki, Masaomi Yamane, Shinichiro Miyoshi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The start of warm ischemic time (WIT) of donor lungs in donation after cardiac death (DCD) is not clearly defined. We investigated the effect of donor pre-mortem hypotension and hypoxia to determine which physiologic factor is the determinant of WIT onset in controlled DCD lung transplantation. Methods: Twenty mechanically-ventilated donor pigs were placed in 4 groups (n = 5 each) and exposed to each of the pseudo-agonal conditions for 60 minutes: (1) control group, no intervention and optimum ventilation, followed by cardiac arrest; (2) hypotension (HT) group, controlled cardiac tamponade reducing systolic blood pressure to

Original languageEnglish
Pages (from-to)445-451
Number of pages7
JournalJournal of Heart and Lung Transplantation
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Warm Ischemia
Lung Transplantation
Hypotension
Controlled Hypotension
Blood Pressure
Transplants
Cardiac Tamponade
Heart Arrest
Ventilation
Swine
Lung
Control Groups
Hypoxia

Keywords

  • definition
  • donation after cardiac death (DCD)
  • hypotension
  • hypoxia
  • lung transplantation
  • warm ischemic time (WIT)

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Effect of donor pre-mortem hypoxia and hypotension on graft function and start of warm ischemia in donation after cardiac death lung transplantation. / Miyoshi, Kentaroh; Oto, Takahiro; Otani, Shinji; Tanaka, Shin; Harada, Masaaki; Kakishita, Tomokazu; Hori, Shiro; Waki, Naohisa; Yamane, Masaomi; Miyoshi, Shinichiro.

In: Journal of Heart and Lung Transplantation, Vol. 30, No. 4, 04.2011, p. 445-451.

Research output: Contribution to journalArticle

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AU - Harada, Masaaki

AU - Kakishita, Tomokazu

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AU - Waki, Naohisa

AU - Yamane, Masaomi

AU - Miyoshi, Shinichiro

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