Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice

Yukio Sugimoto, Chiyomi Taga, Miyuki Nishiga, Madoka Fujiwara, Fumiko Konishi, Kuniaki Tanaka, Chiaki Kamei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Effect of docosahexaenoic acid (DHA) [22:6(n-3)]-fortified Chlorella oil fraction on radial maze performance was studied in aged mice. Male ICR mice aged 9 months were fed a diet containing 2 g DHA-fortified Chlorella oil fraction/100 g diet or normal diet (Control group) for 2 months. Two months after the start of feeding, the mice were tested for learning ability related to 2 types of memory, reference memory and working memory, with the partially (4 of 8) baited eight-arm radial maze. Reference memory is a kind of information that should be retained until the next trial. Working memory is a kind of information that disappears in a short time. Entry into the unbaited arms and repeated entry into the visited arms were defined as reference memory errors and working memory errors, respectively. DHA-fortified Chlorella oil fraction administration to mice for 2 months resulted in a significant decrease in the number of working memory errors without affecting the number of reference memory errors. A significant increase in the DHA content in the brain was also observed. These results suggest that the intake of DHA-fortified Chlorella oil fraction effectively enhances working memory in maze performance.

Original languageEnglish
Pages (from-to)1090-1092
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 2002

Fingerprint

Chlorella vulgaris
Docosahexaenoic Acids
Chlorella
Short-Term Memory
Oils
Diet
Inbred ICR Mouse
Aptitude
Learning
Control Groups
Brain

Keywords

  • Chlorella
  • Docosahexaenoic acid
  • Learning
  • Memory
  • Radial maze

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice. / Sugimoto, Yukio; Taga, Chiyomi; Nishiga, Miyuki; Fujiwara, Madoka; Konishi, Fumiko; Tanaka, Kuniaki; Kamei, Chiaki.

In: Biological and Pharmaceutical Bulletin, Vol. 25, No. 8, 08.2002, p. 1090-1092.

Research output: Contribution to journalArticle

Sugimoto, Yukio ; Taga, Chiyomi ; Nishiga, Miyuki ; Fujiwara, Madoka ; Konishi, Fumiko ; Tanaka, Kuniaki ; Kamei, Chiaki. / Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice. In: Biological and Pharmaceutical Bulletin. 2002 ; Vol. 25, No. 8. pp. 1090-1092.
@article{9744c81c9bc244da850073a657ba3c44,
title = "Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice",
abstract = "Effect of docosahexaenoic acid (DHA) [22:6(n-3)]-fortified Chlorella oil fraction on radial maze performance was studied in aged mice. Male ICR mice aged 9 months were fed a diet containing 2 g DHA-fortified Chlorella oil fraction/100 g diet or normal diet (Control group) for 2 months. Two months after the start of feeding, the mice were tested for learning ability related to 2 types of memory, reference memory and working memory, with the partially (4 of 8) baited eight-arm radial maze. Reference memory is a kind of information that should be retained until the next trial. Working memory is a kind of information that disappears in a short time. Entry into the unbaited arms and repeated entry into the visited arms were defined as reference memory errors and working memory errors, respectively. DHA-fortified Chlorella oil fraction administration to mice for 2 months resulted in a significant decrease in the number of working memory errors without affecting the number of reference memory errors. A significant increase in the DHA content in the brain was also observed. These results suggest that the intake of DHA-fortified Chlorella oil fraction effectively enhances working memory in maze performance.",
keywords = "Chlorella, Docosahexaenoic acid, Learning, Memory, Radial maze",
author = "Yukio Sugimoto and Chiyomi Taga and Miyuki Nishiga and Madoka Fujiwara and Fumiko Konishi and Kuniaki Tanaka and Chiaki Kamei",
year = "2002",
month = "8",
doi = "10.1248/bpb.25.1090",
language = "English",
volume = "25",
pages = "1090--1092",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "8",

}

TY - JOUR

T1 - Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice

AU - Sugimoto, Yukio

AU - Taga, Chiyomi

AU - Nishiga, Miyuki

AU - Fujiwara, Madoka

AU - Konishi, Fumiko

AU - Tanaka, Kuniaki

AU - Kamei, Chiaki

PY - 2002/8

Y1 - 2002/8

N2 - Effect of docosahexaenoic acid (DHA) [22:6(n-3)]-fortified Chlorella oil fraction on radial maze performance was studied in aged mice. Male ICR mice aged 9 months were fed a diet containing 2 g DHA-fortified Chlorella oil fraction/100 g diet or normal diet (Control group) for 2 months. Two months after the start of feeding, the mice were tested for learning ability related to 2 types of memory, reference memory and working memory, with the partially (4 of 8) baited eight-arm radial maze. Reference memory is a kind of information that should be retained until the next trial. Working memory is a kind of information that disappears in a short time. Entry into the unbaited arms and repeated entry into the visited arms were defined as reference memory errors and working memory errors, respectively. DHA-fortified Chlorella oil fraction administration to mice for 2 months resulted in a significant decrease in the number of working memory errors without affecting the number of reference memory errors. A significant increase in the DHA content in the brain was also observed. These results suggest that the intake of DHA-fortified Chlorella oil fraction effectively enhances working memory in maze performance.

AB - Effect of docosahexaenoic acid (DHA) [22:6(n-3)]-fortified Chlorella oil fraction on radial maze performance was studied in aged mice. Male ICR mice aged 9 months were fed a diet containing 2 g DHA-fortified Chlorella oil fraction/100 g diet or normal diet (Control group) for 2 months. Two months after the start of feeding, the mice were tested for learning ability related to 2 types of memory, reference memory and working memory, with the partially (4 of 8) baited eight-arm radial maze. Reference memory is a kind of information that should be retained until the next trial. Working memory is a kind of information that disappears in a short time. Entry into the unbaited arms and repeated entry into the visited arms were defined as reference memory errors and working memory errors, respectively. DHA-fortified Chlorella oil fraction administration to mice for 2 months resulted in a significant decrease in the number of working memory errors without affecting the number of reference memory errors. A significant increase in the DHA content in the brain was also observed. These results suggest that the intake of DHA-fortified Chlorella oil fraction effectively enhances working memory in maze performance.

KW - Chlorella

KW - Docosahexaenoic acid

KW - Learning

KW - Memory

KW - Radial maze

UR - http://www.scopus.com/inward/record.url?scp=0036690402&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036690402&partnerID=8YFLogxK

U2 - 10.1248/bpb.25.1090

DO - 10.1248/bpb.25.1090

M3 - Article

VL - 25

SP - 1090

EP - 1092

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 8

ER -